Publication Date:
2002-09-14
Description:
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Munn, David H -- Sharma, Madhav D -- Lee, Jeffrey R -- Jhaver, Kanchan G -- Johnson, Theodore S -- Keskin, Derin B -- Marshall, Brendan -- Chandler, Phillip -- Antonia, Scott J -- Burgess, Russell -- Slingluff, Craig L Jr -- Mellor, Andrew L -- AI44219/AI/NIAID NIH HHS/ -- AI44759/AI/NIAID NIH HHS/ -- HL60137/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 13;297(5588):1867-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. dmunn@mail.mcg.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12228717" target="_blank"〉PubMed〈/a〉
Keywords:
Antigen-Presenting Cells/enzymology/immunology
;
Antigens, CD/analysis
;
Cell Adhesion
;
Cell Lineage
;
Cells, Cultured
;
Dendritic Cells/*enzymology/*immunology
;
Down-Regulation
;
Enzyme Inhibitors/pharmacology
;
Humans
;
Indoleamine-Pyrrole 2,3,-Dioxygenase
;
Interferon-gamma/pharmacology
;
Interleukin-10/pharmacology
;
Interleukin-3 Receptor alpha Subunit
;
Lymphocyte Activation
;
Lymphocyte Culture Test, Mixed
;
Lymphoid Tissue/cytology/enzymology
;
Macrophages/enzymology
;
Receptors, CCR6
;
Receptors, Chemokine/analysis
;
Receptors, Interleukin-3/analysis
;
T-Lymphocytes/*immunology
;
Tryptophan/*analogs & derivatives/pharmacology
;
Tryptophan Oxygenase/antagonists & inhibitors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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