Publication Date:
1980-01-18
Description:
Studies of the effect of the dopamine agonist apomorphine on local cerebral glucose utilization by means of the carbon-14-labeled deoxyglucose method demonstrate a dose-dependent metabolic activation in the superficial layer of the superior colliculus in the rat. Apomorphine stimulated glucose utilization in a number of other cerebral structures, but only the effect in the superficial layer of the superior colliculus depended on an intact retinal input. This effect was present with the animal in the light or in the dark, but was abolished by enucleation, which left the effects in other cerebral structures unimpaired. Activation of the superificial layer of the superior colliculus appears, therefore, to be secondary to an action of apomorphine on dopaminergic systems within the retina.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCulloch, J -- Savaki, H E -- McCulloch, M C -- Sokoloff, L -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350662" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apomorphine/*pharmacology
;
Dark Adaptation
;
Dopamine/*physiology
;
Functional Laterality
;
Geniculate Bodies/metabolism
;
Glucose/*metabolism
;
Rats
;
Retina/*physiology
;
Superior Colliculi/drug effects/*metabolism
;
Visual Cortex/metabolism
;
Visual Pathways/physiology
;
Visual Perception/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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