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  • 1
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    Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-11-01
    Description: Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prolonged survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Changelian, Paul S -- Flanagan, Mark E -- Ball, Douglas J -- Kent, Craig R -- Magnuson, Kelly S -- Martin, William H -- Rizzuti, Bonnie J -- Sawyer, Perry S -- Perry, Bret D -- Brissette, William H -- McCurdy, Sandra P -- Kudlacz, Elizabeth M -- Conklyn, Maryrose J -- Elliott, Eileen A -- Koslov, Erika R -- Fisher, Michael B -- Strelevitz, Timothy J -- Yoon, Kwansik -- Whipple, David A -- Sun, Jianmin -- Munchhof, Michael J -- Doty, John L -- Casavant, Jeffrey M -- Blumenkopf, Todd A -- Hines, Michael -- Brown, Matthew F -- Lillie, Brett M -- Subramanyam, Chakrapani -- Shang-Poa, Chang -- Milici, Anthony J -- Beckius, Gretchen E -- Moyer, James D -- Su, Chunyan -- Woodworth, Thasia G -- Gaweco, Anderson S -- Beals, Chan R -- Littman, Bruce H -- Fisher, Douglas A -- Smith, James F -- Zagouras, Panayiotis -- Magna, Holly A -- Saltarelli, Mary J -- Johnson, Kimberly S -- Nelms, Linda F -- Des Etages, Shelley G -- Hayes, Lisa S -- Kawabata, Thomas T -- Finco-Kent, Deborah -- Baker, Deanna L -- Larson, Michael -- Si, Ming-Sing -- Paniagua, Ricardo -- Higgins, John -- Holm, Bari -- Reitz, Bruce -- Zhou, Yong-Jie -- Morris, Randall E -- O'Shea, John J -- Borie, Dominic C -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):875-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Group, Department of Antibacterials and Immunology, Pfizer Global Researchand Development, Groton, CT 06340, USA. paul_s_changelian@groton.pfizer.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Enzyme Inhibitors/administration & dosage/pharmacology/therapeutic use/toxicity ; Gene Expression Regulation/drug effects ; Graft Rejection/*prevention & control ; Graft Survival/drug effects ; *Heart Transplantation ; Humans ; Immunosuppressive Agents/administration & dosage/*pharmacology/therapeutic ; use/toxicity ; Interleukin-2/immunology ; Janus Kinase 3 ; *Kidney Transplantation ; Lymphocyte Activation/drug effects ; Lymphocyte Count ; Lymphocyte Culture Test, Mixed ; Lymphocyte Subsets/drug effects ; Macaca fascicularis ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Myocardium/metabolism ; Piperidines ; Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism ; Pyrimidines/administration & dosage/*pharmacology/therapeutic use/toxicity ; Pyrroles/administration & dosage/*pharmacology/therapeutic use/toxicity ; Transplantation, Heterotopic ; Transplantation, Homologous ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Applications of Anaerobic Digestion for the Treatment of Industrial Wastewaters in Europe (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 11 (1997), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: For many decades, anaerobic digestion has been the most important technique of sewage sludge treatment at larger sewage-treatment works. Also, the low running costs of the process make it attractive for the treatment of strong industrial effluents. This paper reviews these advantages and discusses some disadvantages of the anaerobic treatment of industrial effluent. Operating and cost data are presented from Europe and from a detailed UK case study which supports the conclusion that anaerobic treatment will be the most cost-effective method of treatment of strong industrial effluents such as those from food and paper processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.1997.tb00086.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of soluble starch synthases and branching enzymes from developing maize and teosinte seeds
    Amsterdam : Elsevier
    Phytochemistry 23 (1984), S. 737 
    Details
    ISSN: 0031-9422
    Keywords: ADP glucose: α-1,4-glucan-4glucosyl transferases. ; Gramineae ; Zea species ; branching enzume ; maize ; starch synthesis ; teosine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)85014-1
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  • 4
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    Global intercomparison of 12 land surface heat flux estimates (2011)
    Wiley
    Details
    Publication Date: 2011-01-20
    Description: A global intercomparison of 12 monthly mean land surface heat flux products for the period 1993–1995 is presented. The intercomparison includes some of the first emerging global satellite-based products (developed at Paris Observatory, Max Planck Institute for Biogeochemistry, University of California Berkeley, University of Maryland, and Princeton University) and examples of fluxes produced by reanalyses (ERA-Interim, MERRA, NCEP-DOE) and off-line land surface models (GSWP-2, GLDAS CLM/Mosaic/Noah). An intercomparison of the global latent heat flux (Qle) annual means shows a spread of ∼20 W m−2 (all-product global average of ∼45 W m−2). A similar spread is observed for the sensible (Qh) and net radiative (Rn) fluxes. In general, the products correlate well with each other, helped by the large seasonal variability and common forcing data for some of the products. Expected spatial distributions related to the major climatic regimes and geographical features are reproduced by all products. Nevertheless, large Qle and Qh absolute differences are also observed. The fluxes were spatially averaged for 10 vegetation classes. The larger Qle differences were observed for the rain forest but, when normalized by mean fluxes, the differences were comparable to other classes. In general, the correlations between Qle and Rn were higher for the satellite-based products compared with the reanalyses and off-line models. The fluxes were also averaged for 10 selected basins. The seasonality was generally well captured by all products, but large differences in the flux partitioning were observed for some products and basins.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Importance of patient selection when determining the significance of the CYP3A5 polymorphism in clinical trials (2004)
    Springer Nature
    Details
    Publication Date: 2004-10-12
    Print ISSN: 1470-269X
    Electronic ISSN: 1473-1150
    Topics: Chemistry and Pharmacology
    Published by Springer Nature
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  • 6
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    Ground heat flux: an analytical review of 6 models evaluated at 88 sites and globally (2016)
    Wiley
    Details
    Publication Date: 2016-11-29
    Description: Uncertainty in ground heat flux (G) means that evaluation of the other terms in the surface energy balance (e.g., latent and sensible heat flux, LE and H ) remains problematic. Algorithms that calculate LE and H require available energy, the difference between net radiation, R NET , and G. There are a wide range of approaches to model G for large-scale applications, with a subsequent wide range of estimates and accuracies. We provide the largest review of these methods to date (N = 6), evaluating modeled G against measured G from 88 FLUXNET sites. The instantaneous mid-day variability in G is best captured by models forced with net radiation, while models forced by temperature show the least error at both instantaneous and daily timescales. We produce global decadal datasets of G to illustrate regional and seasonal sensitivities, as well as uncertainty. Global model mean mid-morning instantaneous G is highest during September, October, and November at 63.42 (+/- 16.84) Wm -2 while over December, January, and February G is lowest at 53.86 (+/- 18.09) Wm -2 but shows greater inter-model uncertainty. Results from this work have the potential to improve ET estimates and guide appropriate G model selection and development for various land uses.
    Print ISSN: 0148-0227
    Topics: Biology , Geosciences
    Published by Wiley on behalf of American Geophysical Union (AGU).
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