ALBERT

Description: Background: Nuclear receptors are a superfamily of transcription factors important in key biological, developmental and reproductive processes. Several of these receptors are ligand- activated and through their ability to bind endogenous and exogenous ligands, are potentially vulnerable to xenobiotics. Molluscs are key ecological species in defining aquatic and terrestrial habitats and are sensitive to xenobiotic compounds in the environment. However, the understanding of nuclear receptor presence, function and xenobiotic disruption in the phylum Mollusca is limited. Results: Here, forty-three nuclear receptor sequences were mined from the genome of the Pacific oyster, Crassostrea gigas. They include members of NR0-NR5 subfamilies, notably lacking any NR6 members. Phylogenetic analyses of the oyster nuclear receptors have been conducted showing the presence of a large novel subfamily group not previously reported, which is named NR1P. Homologues to all previous identified nuclear receptors in other mollusc species have also been determined including the putative heterodimer partner retinoid X receptor, estrogen receptor and estrogen related receptor. Conclusion: C. gigas contains a highly diverse set of nuclear receptors including a novel NR1 group, which provides important information on presence and evolution of this transcription factor superfamily in invertebrates. The Pacific oyster possesses two members of NR3, the sex steroid hormone receptor analogues, of which there are 9 in humans. This provides increasing evidence that steroid ligand specific expansion of this family is deuterostome specific. This new knowledge on divergence and emergence of nuclear receptors in C. gigas provides essential information for studying regulation of molluscan gene expression and the potential effects of xenobiotics.

Description: A human mission to Mars would present an unprecedented opportunity to investigate the earliest history of the solar system. This history that has largely been overwritten on Earth by active geological processing throughout its history, but on Mars, large swaths of the ancient crust remain exposed at the surface, allowing us to investigate martian processes at the earliest time periods when life first appeared on the Earth. Mars' surface has been largely frozen in place for 4 billion years, and after losing its atmosphere and magnetic field what re-mains is an ancient landscape of former hydrothermal systems, river beds, volcanic eruptions, and impact craters. This allows us to investigate scientific questions ranging from the nature of the impact history of the solar system to the origins of life. We present here a summary of the findings of the Human Science Objectives Science Analysis Group, or HSO-SAG chartered by MEPAG in 2015 to address science objectives and landing site criteria for future human missions to Mars (Niles, Beaty et al. 2015). Currently, NASA's plan to land astronauts on Mars in the mid 2030's would allow for robust human exploration of the surface in the next 35 years. We expect that crews would be able to traverse to sites up to 100 km away from the original landing site using robust rovers. A habitat outfitted with state of the art laboratory facilities that could enable the astronauts to perform cutting edge science on the surface of Mars. Robotic/human partnership during exploration would further enhance the science return of the mission.