ISSN:
1573-904X
Keywords:
capillary electrophoresis
;
pharmaceutical analysis
;
detection
;
metabolites
;
pretreatment
;
preconcentration
;
chiral separations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Capillary electrophoresis (CE) is a separation technique particularly suited to the analysis of pharmaceutical compounds. This review offers a detailed discussion of the four common modes of detection coupled to CE—UV absorption, fluorescence, electrochemical, and mass spectrometry—and gives examples of the use of these methods in pharmaceutical analyses. Sample preparation and pretreatment techniques used for CE separations are described, as well as methods of preconcentration including hydrophobic retention, affinity concentration, sample stacking, and isotachophoresis. The use of affinity CE, chiral CE, and capillary gel electrophoresis for analysis of pharmaceuticals is covered in detail, and recent advances in capillary electrochromatography and CE on a chip are also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1012018709641
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