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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the effect of toxin T-514 on the integrity of peroxisomes in methylotrophic yeasts (1992)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 91 (1992), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract We have studied the response of two methylotrophic yeasts (Hansenula polymorpha and Candida boidinii) to toxin T-514, a toxin lethal to man, extracted from the shrub Karwinska homboldtiana. Growth experiments indicated a dose-response effect; at enhanced concentrations (50 μg/ml) the different subcellular organelles rapidly disintegrated resulting in death of the cultures. At non-lethal concentrations (〈2μg/ml) growth ceased initially, but resumed after a lag period of 4 h. At the subcellular level a specific effect was observed on peroxisomal integrity. Distinct holes appeared in the peroxisomal membranes, resulting in leakage of matrix proteins from these organelles. In addition, import of newly synthesized proteins appeared to be blocked since cytosolic aggregates of matrix proteins were formed. The peroxisomal damage was probably irreversible since affected organelles were degraded at later stages of incubation. Upon restoration of growth on methanol, new peroxisomes developed from those which had escaped degradation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05210.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tissue culture ofKarwinskia humboldtiana—a plant producing toxins with antitumoural effects (1994)
    Springer
    Plant cell, tissue and organ culture 36 (1994), S. 339-343 
    Details
    ISSN: 1573-5044
    Keywords: callus and organ cultures ; Karwinskia humboldtiana (Zucc.) ; Rhamnaceae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Isolated embryos ofKarwinskia humboldtiana were cultured in vitro. The growth of embryos and development to plantlets on woody plant medium supplemented with indole-3-acetic acid 6.10-2 μmol l−1, gibberellic acid (GA3) 3.10-2 μmol l−1, and 6-benzylaminopurine (BA) 2 μmol l−1 was obtained. Multiplication of shoots and rooting of excised shoots has been achieved. Callus formation on modified Murashige-Skoog medium supplemented with 1-naphthaleneacetic acid 10 μmol l−1, GA3 14 μmol l−1, and kinetin 5 μmol l−1 on hypocotyls, or on root cultures on medium supplemented with 2.4-dichlorophenoxyacetic acid 10 μmol l−1 and BA 10 μmol l−1 was induced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00046091
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