ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Measurement of blood-brain barrier permeation in rats during exposure to 2450-MHz microwaves (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 3 (1982), S. 371-383 
    Details
    ISSN: 0197-8462
    Keywords: blood-brain barrier ; rats ; 2450-MHz microwaves ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Adult rats anesthesized with pentobarbital and injected intravenously with a mixture of [14C]sucrose and [3H]inulin were exposed for 30 min to an environment at an ambient temperature of 22, 30, or 40 °C, or were exposed at 22 °C to 2450-MHz CW microwave radiation at power densities of 0, 10, 20, or 30 mW/cm2. Following exposure, the brain was perfused and sectioned into eight regions, and the radioactivity in each region was counted. The data were analyzed by two methods. First, the data for each of the eight regions and for each of the two radioactive tracers were analyzed by regression analysis for a total of 16 analyses and Bonferroni's Inequality was applied to prevent false positive results from numerous analyses. By this conservative test, no statistically significant increase in permeation was found for either tracer in any brain region of rats exposed to microwaves. Second, a profile analysis was used to test for a general change in tracer uptake across all brain regions. Using this statistical method, a significant increase in permeation was found for sucrose but not for inulin. A correction factor was then derived from the warm-air experiments to correct for the increase in permeation of the brain associated with change in body temperature. This correction factor was applied to the data for the irradiated animals. After correcting the data for thermal effects of the microwave radiation, no significant increase in permeation was found.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250030309
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    facet.materialart.
    Unknown
    Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity (2015)
    Oxford University Press
    Details
    Publication Date: 2015-08-29
    Description: To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Heterogeneous seismic anisotropy in the transition zone and uppermost lower mantle: evidence from South America, Izu-Bonin and Japan (2015)
    Oxford University Press
    Details
    Publication Date: 2015-04-12
    Description: Measurements of seismic anisotropy are commonly used to constrain deformation in the upper mantle. Observations of anisotropy at mid-mantle depths are, however, relatively sparse. In this study we probe the anisotropic structure of the mid-mantle (transition zone and uppermost lower mantle) beneath the Japan, Izu-Bonin, and South America subduction systems. We present source-side shear wave splitting measurements for direct teleseismic S phases from earthquakes deeper than 300 km that have been corrected for the effects of upper mantle anisotropy beneath the receiver. In each region, we observe consistent splitting with delay times as large as 1 s, indicating the presence of anisotropy at mid-mantle depths. Clear splitting of phases originating from depths as great as ~600 km argues for a contribution from anisotropy in the uppermost lower mantle as well as the transition zone. Beneath Japan, fast splitting directions are perpendicular or oblique to the slab strike and do not appear to depend on the propagation direction of the waves. Beneath South America and Izu-Bonin, splitting directions vary from trench-parallel to trench-perpendicular and have an azimuthal dependence, indicating lateral heterogeneity. Our results provide evidence for the presence of laterally variable anisotropy and are indicative of variable deformation and dynamics at mid-mantle depths in the vicinity of subducting slabs.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    A contrast in anisotropy across mid-lithospheric discontinuities beneath the central United States--A relic of craton formation (2014)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2014-09-20
    Description: The mid-lithospheric discontinuity (MLD) is a seemingly sharp decrease in seismic velocity at depths internal to the lithosphere and appears to be a pervasive feature beneath continental interiors. Its presence within cratons, which have remained relatively stable since formation, suggests that the MLD may result from processes associated with continent formation. We use P- to S-wave receiver functions to interrogate seismic anisotropy across the MLD within the ca. 1.35–1.55 Ga Granite-Rhyolite Province of the central United States. Our analysis reveals strong evidence for sharp changes in the orientation of anisotropy across multiple MLDs, with an approximately north to northwest fast orientation of anisotropy in the upper lithosphere. The consistency of this signature over a large region suggests that the observed anisotropy is a relic of North American craton formation. In addition, the presence of several distinct anisotropic layers within the cratonic lithosphere supports models for craton formation via stacked subducted slabs or a series of underthrusting events.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    A Markov chain Monte Carlo with Gibbs sampling approach to anisotropic receiver function forward modeling (2016)
    Oxford University Press
    Details
    Publication Date: 2016-11-10
    Description: Teleseismic receiver functions contain information regarding Earth structure beneath a seismic station. P -to- SV converted phases are often used to characterize crustal and upper-mantle discontinuities and isotropic velocity structures. More recently, P -to- SH converted energy has been used to interrogate the orientation of anisotropy at depth, as well as the geometry of dipping interfaces. Many studies use a trial-and-error forward modeling approach for the interpretation of receiver functions, generating synthetic receiver functions from a user-defined input model of Earth structure and amending this model until it matches major features in the actual data. While often successful, such an approach makes it impossible to explore model space in a systematic and robust manner, which is especially important given that solutions are likely non-unique. Here, we present a Markov chain Monte Carlo algorithm with Gibbs sampling for the interpretation of anisotropic receiver functions. Synthetic examples are used to test the viability of the algorithm, suggesting that it works well for models with a reasonable number of free parameters (〈~20). Additionally, the synthetic tests illustrate that certain parameters are well constrained by receiver function data, while others are subject to severe trade-offs—an important implication for studies that attempt to interpret Earth structure based on receiver function data. Finally, we apply our algorithm to receiver function data from station WCI in the central United States. We find evidence for a change in anisotropic structure at mid-lithospheric depths, consistent with previous work that used a grid search approach to model receiver function data at this station. Forward modeling of receiver functions using model space search algorithms, such as the one presented here, provide a meaningful framework for interrogating Earth structure from receiver function data.
    Keywords: Seismology
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Book Review: Geophysical Data Analysis: Discrete Inverse Theory (MATLAB Edition), Third edition by William Menke (2017)
    Mineralogical Society of America
    Details
    Publication Date: 2017-01-04
    Print ISSN: 0003-004X
    Electronic ISSN: 1945-3027
    Topics: Geosciences
    Published by Mineralogical Society of America
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    The Field Experiences for Science Teachers (FEST) Program: Involving Connecticut High School Science Teachers in Field Seismology (2017)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2017-02-24
    Description: The Field Experiences for Science Teachers (FEST) Program, based in the Department of Geology and Geophysics at Yale University, provides field seismology experiences to secondary school science teachers in Connecticut. Research experiences for K-12 science teachers have been shown in the past to improve students’ test scores and encourage inquiry-based teaching in the science classroom. FEST provides one-week sessions for teachers that include one day of orientation and four days of field work experience on the 15-station broadband Seismic Experiment for Imaging Structure beneath Connecticut. Here, I describe the FEST program, including strategies for teacher recruitment, the structure of the program, and lessons learned from the first three program sessions. FEST has demonstrated that field seismology experiments can provide high school teachers with a fun, engaging, and highly immersive field experience that provides a benefit that is out of proportion to a relatively modest time commitment. Participation in FEST has exposed teacher participants to concepts in seismology, introduced them to resources for teaching about seismology in their classroom, and provided them with a meaningful summer research experience.
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America (SSA)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Evaluating geodynamic models for sub-slab anisotropy: Effects of olivine fabric type (2017)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2017-04-01
    Description: We examine spatially varying patterns of sub-slab anisotropy derived from geodynamic models of subduction beneath Central America and Tonga. Invoking a variety of anisotropic fabrics, we compare the predicted sub-slab anisotropy of these models against source-side, shear-wave splitting observations using realistic ray paths. We find that in both regions fabric type has a strong impact on predicted shear-wave splitting. In Tonga, where three-dimensional (3D) return flow dominates, E-type olivine lattice-preferred orientation (LPO) fabric predicts a sub-slab mantle anisotropy that best matches observations. In Central America, where entrained flow dominates, anisotropy from C-type LPO fabric yields the best fit. This highlights the importance of fabric type when interrogating geodynamic models because different regions may be characterized by different LPO fabrics. A primary controller of fabric type is water content. Taken at face value, these results then suggest the sub-slab mantle beneath Tonga is less well hydrated than that beneath Central America.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas (2018)
    Springer Nature
    Details
    Publication Date: 2018-12-01
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    On the relationship between azimuthal anisotropy from shear wave splitting and surface wave tomography (2012)
    American Geophysical Union
    Details
    Publication Date: 2012-01-01
    Print ISSN: 0148-0227
    Electronic ISSN: 2156-2202
    Topics: Geosciences
    Published by American Geophysical Union
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...