Publication Date:
2014-03-16
Description:
Eight new metabolites, including five new sesquiterpenoids, 10,11-epoxyguaian-10-ol ( 1 ), 10,11-epoxyguaian-13-ol ( 2 ), a new backbone sesquiterpene rearranged from guaiane ( 3 ), two 1,5 : 1,10-disecoguaianes, 4 and 5 , two new dihydroisocoumarins, 7-chloromellein-4-ol ( 6 ) and 7-chloromellein-5-ol ( 7 ), and one new tetralone, 7-chloroscytalone ( 8 ), were isolated from the mutant strain G-444 of Tubercularia sp. TF5, an endophytic fungus of Taxus mairei , along with ten known compounds, 3,4-dihydro-4,8-dihydroxy-2 H -naphthalen-1-one ( 9 ), (3 R ,4 S )-4-hydroxymellein ( 10 ), 5-formylmellein ( 11 ), 5-carboxymellein ( 12 ), sporogen-AO1 ( 13 ), tuberculariols A ( 14 ) and B ( 15 ), hymatoxin E ( 16 ), 4-oxo-4 H -pyran-3-acetic acid ( 17 ), and penicillic acid ( 18 ) . Their structures were elucidated by spectroscopic analyses including HR-ESI-MS, 1D- and 2D-NMR (HMQC, HMBC, 1 H, 1 H-COSY and NOESY). The antimicrobial activities of 1 – 8 were evaluated, but none showed any substantial effect.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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