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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research DNA Repair Reports 112 (1983), S. 253-260 
    ISSN: 0167-8817
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 334 (1988), S. 359-362 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Microtubules are hollow cylinders made of tubulin and various microtubule-associated proteins (MAPs), including tau protein. Tau is actually a mixture of four to five related polypep-tides, one of which has been sequenced4. It is heat stable and soluble in perchloric acid5'6 and these properties ...
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 1988-07-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 4
    Publication Date: 2011-08-24
    Description: Space sickness symptoms were observed by 4 specially trained observers on Spacelab-1. Three reported persistent symptoms, and vomited repeatedly during the first and/or second day of flight. Head movements on all axes were provocative, particularly in pitch and roll. Head acceleration data recorded from 2 symptomatic crewmen showed that after several hours of physical activity in orbit, symptoms appeared, and thereafter both crewmen were compelled to limit head movements. Firm body contact with motionless surfaces helped alleviate symptoms. When crewmembers floated into unfamiliar body orientations in the cabin, inherent ambiguities in static visual orientation cues sometimes produced spatial reorientation episodes which were also provocative. Symptoms largely resembled those of other forms of prolonged motion sickness, superimposed upon other symptoms attributable to fluid shift. All 4 eventually used anti-motion sickness drugs. When they did, vomiting frequency was reduced. By the 4th day, symptoms subsided, and head accelerations again increased in magnitude and variability. Sickness intensity in orbit was not predicted by statistically concordant results of 6 acute preflight susceptibility tests. However, results from a longer duration preflight prism goggles test showed an apparent correlation. All subjects were asymptomatic making head movements in parabolic flight 4 days after the mission, but not 1 year later. Overall, results support the view that space sickness is a motion sickness.
    Keywords: Aerospace Medicine
    Type: Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale (ISSN 0014-4819); Volume 64; 2; 316-34
    Format: text
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  • 5
    Publication Date: 2004-10-30
    Keywords: AEROSPACE MEDICINE
    Type: INSI02 Vestibular Experiments on Spacelab-1; 47 p
    Format: text
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  • 6
    Publication Date: 2004-10-30
    Keywords: AEROSPACE MEDICINE
    Type: INSI02 Vestibular Experiments on Spacelab-1; 22 p
    Format: text
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  • 7
    Publication Date: 2011-08-24
    Description: This paper will describe the biomedical support aspects of humans in space with respect to the vestibular system. The vestibular system is thought to be the primary sensory system involved in the short-term effects of space motion sickness although there is increasing evidence that many factors play a role in this complex set of symptoms. There is the possibility that an individual's inner sense of orientation may be strongly coupled with the susceptibility to space motion sickness. A variety of suggested countermeasures for space motion sickness will be described. Although there are no known ground-based tests that can predict space motion sickness, the search should go on. The long term effects of the vestibular system in weightlessness are still relatively unknown. Some preliminary data has shown that the otoconia are irregular in size and distribution following extended periods of weightlessness. The ramifications of this data are not yet known and because the data was obtained on lower order animals, definitive studies and results must wait until the space station era when higher primates can be studied for long durations. This leads us to artificial gravity, the last topic of this paper. The vestibular system is intimately tied to this question since it has been shown on Earth that exposure to a slow rotating room causes motion sickness for some period of time before adaptation occurs. If the artificial gravity is intermittent, will this mean that people will get sick every time they experience it? The data from many astronauts returning to Earth indicates that a variety of sensory illusions are present, especially immediately upon return to a 1-g environment. Oscillopsia or apparent motion of the visual surround upon head motion along with inappropriate eye motions for a given head motion, all indicate that there is much to be studied yet about the vestibular and CNS systems reaction to a sudden application of a steady state acceleration field like 1-g. From the above information it is obvious that the vestibular system does have unique requirements when it comes to the biomedical support of space flight. This is not to say that other areas such as cardiovascular, musculo-skeletal, immunological and hematological systems do not have their own unique requirements but that possible solutions to one system can provide continuing problems to another system. For example, artificial gravity might be helpful for long term stabilization of bone demineralization or cardiovascular deconditioning but might introduce a new set of problems in orientation, vestibular conflict and just plain body motion in a rotating space vehicle.
    Keywords: Aerospace Medicine
    Type: Acta astronautica (ISSN 0094-5765); Volume 17; 2; 203-6
    Format: text
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  • 8
    Publication Date: 2011-08-18
    Description: Various operational aspects of the Spacelab 1 mission are reviewed by the four payload crew members. Two-shift operations, voice communication with ground investigators, joint participation in experiment activity, Spacelab performance, and recent advances are discussed.
    Keywords: ASTRONAUTICS (GENERAL)
    Type: Science (ISSN 0036-8075); 225; 165-167
    Format: text
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  • 9
    Publication Date: 2013-08-31
    Description: Experiments on human spatial orientation were conducted on four crewmembers of Space Shuttle Spacelab Mission 1. The conceptual background of the project, the relationship among the experiments, and their relevance to a 'sensory reinterpretation hypothesis' are presented. Detailed experiment procedures and results are presented in the accompanying papers in this series. The overall findings are discussed as they pertain to the following aspects of hypothesized sensory reinterpretation in weightlessness: (1) utricular otolith afferent signals are reinterpreted as indicating head translation rather than tilt, (2) sensitivity of reflex responses to footward acceleration is reduced, and (3) increased weighting is given to visual and tactile cues in orientation perception and posture control. Results suggest increased weighting of visual cues and reduced weighting of graviceptor signals in weightlessness.
    Keywords: AEROSPACE MEDICINE
    Type: NASA. Lyndon B. Johnson Space Center, Spacelab Life Sciences 1: Reprints of Background Life Sciences Publications; p 346-353
    Format: application/pdf
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  • 10
    Publication Date: 2017-10-02
    Description: It is hypothesized that exposure to prolonged free fall is a form of sensory/motor rearrangement rather than a direct change in otolith sensitivity or sensory compensation for a reduced otolith input. The rearrangement of stimuli will force a new interpretation by the CNS of otolith input. This reinterpretation is necessary for a structured and meaningful interaction with the new environment. Data from two flight experiments are presented which support an otolith reinterpretation hypothesis. The first experiment measured vestibulo-spinal reflex changes as a function of sustained free fall. Findings indicate that when a monosynaptic reflex (H-reflex), measured from the major postural muscles (soleus), is used adaptation to space flight includes a change in how the CNS interprets a fall. In a normal gravity environment a sudden unexpected fall will produce a potentiated H reflex. After seven days in flight an equivalent fall does not potentiate the reflex. During postflight a greatly increased reflex is observed in those crewmen most susceptible to space motion sickness. In the second experiment self motion perception and torsional eyemovements were modified as a function of exposure to sustained free fall. Preflight roll motion (about the X axis) was perceived as pure roll, and the eye movements recorded were countertorsional. Postflight, roll stimulation was perceived as linear translation (side to side movement) with a small angular motion component. Eye movement measurements confirmed significantly more horizontal motion.
    Keywords: AEROSPACE MEDICINE
    Type: AGARD Results of Space Expt. in Physiol. and Med. and Informal Briefings by the F-16 Med. Working Group; 18 p
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