ISSN:
1662-9752
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) modelwith a nonlinear elasticity law developed to describe the compaction behavior of pharmaceuticalpowders. The model is implemented in ABAQUS with a user subroutine. Using microcrystallinecellulose (MCC) Avicel PH101 as an example, the modified DPC model is calibrated and used forfinite element simulations of uniaxial single-ended compaction in a cylindrical die. To validate theproposed model, finite element simulation results of powder compaction are compared withexperimental results. It was found that finite element analyses gave a good prediction of both theloading-unloading curves during powder compaction and the compaction force required for makinga tablet with a specified density. Further, the failure mechanisms of chipping, lamination andcapping during tabletting are investigated by analysing the stress and density distributions ofpowders during the three different phases of the tabletting processes, i.e. compression,decompression and ejection. The results indicate that the model has excellent potential to describethe compaction process for generic pharmaceutical powders
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.560.pdf
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