ISSN:
0021-8995
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
,
Physics
Notes:
The copolymers poly(propylene-co-ethylene) (PP/E) and poly(ethylene-co-vinyl acetate) (EVA) and blends of these were modified to develop an artificial matrix which promotes the growth of endothelial cells. Covalent immobilization of amino acids or sequences of adhesion glycoproteins should trigger the formation of an endothelial cell monolayer onto the polymeric surface. Reactive functional groups were generated by saponifying the ester groups of the EVA component. Esterification with oxalylic or malonic dichlorides in the gas phase yielded the required monoesters and gave the best results for further immobilization of amino acids, while reaction with α,ω-dicarboxylic acid dichlorides in solution led to diester formation. Subsequently, various protected amino acids were immobilized via the carbodiimide method. Surface analytical methods like infrared spectroscopy using at tenuated total reflection (IR-ATR), X-ray photoelectron spectroscopy (XPS), and secondary ion mass spectrometry (SIMS) were used to prove the modification steps. The analytical results confirmed covalent side-chain generation in the upper surface region. © 1995 John Wiley & Sons, Inc.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/app.1995.070580403
Permalink