ISSN:
1476-4687
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Notes:
[Auszug] The serpin reactive centre is believed to act as a pseudosub-strate for the target protease. The inhibitor and protease form a tight complex with potential cleavage at a Pt - Pi peptide bond (Table 1). The P! site primarily defines specificity of inhibition; for example antithrombin, which inhibits ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/347099a0
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