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  • 1
    Monograph available for loan
    Monograph available for loan
    Mikroklimatische Untersuchungen der Abkühlungsgröße in einem Waldgebiete (1936)
    Leipzig : Noske
    Associated volumes
    Details Availability
    Call number: MOP Per 469(7,4)
    In: Veröffentlichungen des Geophysikalischen Instituts der Universität Leipzig
    Type of Medium: Monograph available for loan
    Pages: S. 189 - 255 , Ill., graph. Darst.
    Series Statement: Veröffentlichungen des Geophysikalischen Instituts der Universität Leipzig : Zweite Serie, Spezialarbeiten aus dem Geophysikalischen Institut und Observatorium 7,4
    Note: Zugl.: Leipzig, Univ., Diss., 1936
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 2
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    Pathomechanisms of Paclitaxel-Induced Peripheral Neuropathy (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-09-22
    Description: Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces neuropathy in up to 97% of all gynecological and urological cancer patients. In cancer cells, paclitaxel induces cell death via microtubule stabilization interrupting cell mitosis. However, paclitaxel also affects cells of the central and peripheral nervous system. The main symptoms are pain and numbness in hands and feet due to paclitaxel accumulation in the dorsal root ganglia. This review describes in detail the pathomechanisms of paclitaxel in the peripheral nervous system. Symptoms occur due to a length-dependent axonal sensory neuropathy, where axons are symmetrically damaged and die back. Due to microtubule stabilization, axonal transport is disrupted, leading to ATP undersupply and oxidative stress. Moreover, mitochondria morphology is altered during paclitaxel treatment. A key player in pain sensation and axonal damage is the paclitaxel-induced inflammation in the spinal cord as well as the dorsal root ganglia. An increased expression of chemokines and cytokines such as IL-1β, IL-8, and TNF-α, but also CXCR4, RAGE, CXCL1, CXCL12, CX3CL1, and C3 promote glial activation and accumulation, and pain sensation. These findings are further elucidated in this review.
    Electronic ISSN: 2305-6304
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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    PAPER CURRENT
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