ISSN:
0170-2041
Keywords:
Nucleosides
;
Antiviral agent
;
Azido nucleoside
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The α,β-unsaturated D-sugar aldehyde 2, prepared from tri-O-acetyl-D-glucal, was converted into 1-O-acetyl-3-azido-2,3-dideoxy-α-D-arabino-pyranose (3) by reaction with sodium azide in a mixture of acetic acid and water followed by acetylation. Reaction of 3 with silylated pyrimidines using TMS triflate as catalyst followed by deprotection with saturated ammonia in methanol afforded 3′-azido-2′,3′-dideoxy-β-D-arabino-hexopyranosyl nucleosides 4.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1990199001194
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