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  • 1
    Electronic Resource
    Electronic Resource
    A hierarchy of responsiveness and the production of nonprecipitating antibodies to F antigen (1979)
    Springer
    Immunogenetics 8 (1979), S. 65-70 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The immune response to F antigen by a variety of inbred strains and F1 hybrids has been studied. All of the mice responding to appropriate preparations of F antigen share ak allele atH-2K orI-A. In F1 hybrids, however, this permissive gene is sometimes expressed as dominant responsiveness, while in other combinations as dominant nonresponsiveness. There appears to be a hierarchy of responsiveness among the responder strains tested. Finally, some strains produce nonprecipitating antibodies against F antigen which may represent a genetically controlled restriction of the response to this antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561414
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  • 2
    Electronic Resource
    Electronic Resource
    Polygenic control of the immune response to F antigen (1981)
    Springer
    Immunogenetics 12 (1981), S. 237-251 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The ability to produce an autoimmune response to F antigen in mice is underH-2-linked and non-H- 2-linkedIr-gene control. There is an absolute requirement for ak allele atH-2K orI-A in order to produce anti-F antibodies. Low and high responsiveness is controlled by a non-H-2-linkedIr gene which behaves in a similar fashion toIr-3, in that as the dose of F-antigen is lowered, low responders behave as high responders and vice versa. This conversion from low to high responsiveness also occurs within a month after ATX.— Most F1 hybrids derived from (responder x nonresponder) parents bearing identical F-types behave as dominant nonresponders. As a result of ATX, such F1 mice convert to high responders. This conversion occurs if the animals are not immunized before day 90. If they receive F antigen prior to that time, they remain nonresponders for 7–9 months. One F1 combination — AKD2 — behaves as a dominant high responder. Genetic analysis showed that in the presence of ak allele atH-2K orI-A, a non-H-2-linkedIr gene inherited from the AKR mice determined dominant responsivenss. No manipulation of the immune response or combination of genes converted nonresponders lacking ak allele into responders. Such complex genetic control suggests regulation by a number of independently segregating loci whose function it is to limit the autoimmune response to F antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561667
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of the gene locus controlling dominant nonresponsiveness to F-antigen (1977)
    Springer
    Immunogenetics 4 (1977), S. 295-299 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575668
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  • 4
    Electronic Resource
    Electronic Resource
    Turning the key on p53 (2004)
    [s.l.] : Nature Publishing Group
    Nature 427 (2004), S. 789-790 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Almost exactly 25 years ago, a report appeared describing the interaction between a cancer-causing virus and a host protein dubbed 53K. That entity, since called p53 and recognized as a tumour-suppressor protein because of its ability to prevent undue cell proliferation, has attracted ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/427789a
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  • 5
    Electronic Resource
    Electronic Resource
    Requirement for the replication protein SSB in human DMA excision repair (1991)
    [s.l.] : Nature Publishing Group
    Nature 349 (1991), S. 538-541 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The extent of nucleotide excision repair can be assessed in vitro by incubating damaged and nondamaged circular plasmid DNA with whole-cell extracts8 from human cell lines in a reaction mixture which includes the four deoxynucleoside triphosphates and [a-32P]dATP. Enzymes in the extract carry out ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/349538a0
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  • 6
    Electronic Resource
    Electronic Resource
    Protein synthesis required to anchor a mutant p 53 protein which is temperature-sensitive for nuclear transport (1991)
    [s.l.] : Nature Publishing Group
    Nature 349 (1991), S. 802-806 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Clone 6 cells, a line of rat embryo fibroblasts transformed by a temperature-sensitive mutant p53 gene and an activated ras gene1 were stained with four different anti-p53 monoclonal antibodies2'3 at 37 °C and 32 °C. All four antibodies used independently showed the same result. At 37 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/349802a0
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  • 7
    Electronic Resource
    Electronic Resource
    Killing tumor cells with viruses—a question of specificity (1998)
    [s.l.] : Nature America Inc.
    Nature medicine 4 (1998), S. 1012-1013 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The selective action of a replication-competent, E1B-deficient adenovirus therapy for cancer is challenged in a new study (pages ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2000
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  • 8
    Electronic Resource
    Electronic Resource
    Tumour diagnosis (1994)
    [s.l.] : Nature Publishing Group
    Nature 369 (1994), S. 701-701 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR — The ability to refine pathological diagnosis and improve its objectivity, particularly in the context of small biopsies and cytological material, has been dramatically demonstrated by the case of Hubert Humphrey's bladder cancer (Nature 369, 13; 1994). However, for this approach to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/369701c0
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  • 9
    Electronic Resource
    Electronic Resource
    The dominating effect of mutant p53 (1995)
    [s.l.] : Nature Publishing Group
    Nature genetics 9 (1995), S. 221-222 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In most human tumours, both copies of the normalp53 gene are inactivated. Commonly one allele is completely deleted; however, the other allele is frequently retained but inactivated by missense mutations, typically somewhere in the central conserved DNA binding domain1–3. This unusual ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0395-221
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  • 10
    Electronic Resource
    Electronic Resource
    Immunohistochemical and Ultrastructural Evidence for Myelopoiesis in the Scid/scid Mouse Thymus (1999)
    Springer
    Journal of molecular histology 31 (1999), S. 651-660 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The ultrastructure of scid mouse thymus (a small encapsulated epithelial mass within the precardial fat pad) is described. The epithelium did not form cortex or medulla and hence remained relatively undifferentiated. Small unmyelinated nerves innervated the capsule, the major blood vessels and were distributed between the epithelial cells. Fenestrated blood vessels were common. Thymocytes were not identified but numeous granulocytes, mast cells and some fibroblasts, macrophages and interdigitating cells were present. All stages of granulopoiesis were observed in scid thymus. A very small number of immunoreactive ER-MP58 cells indicated bone marrow derived myeloid precursor cells, and low numbers of ER-MP12+ and ER-MP20+ mononuclear cells indicated stages of myeloid cells committed to the granulocyte/macrophage lineage. Cells containing proliferating nuclear cell antigen (cells in G1, S and G2-M stage) were present throughout the thymic mass. BALB/c thymuses contained cortical foci of p53+ cells whereas in scid mice, p53 positive cells were scattered singly throughout the thymus. This study indicates that the presence of moderately extensive myelopoiesis within the scid mouse thymus has potential for the study of extramedullary hematopoiesis, and also is important to bear this function in mind when using the scid mouse as an immunological model for thymus reconstitution and for creating ‘organoid’ cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003895519669
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