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  • 1
    Keywords: Microbiology. ; Pharmacology. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Microbiology. ; Pharmacology. ; Medical Microbiology. ; Translational Research.
    Description / Table of Contents: 1. Microbial Diversity and Their Role in Human Health and Diseases -- Section I: Gut Microbes and Perspectives -- 2. Emerging Microbial Identification Technologies in the Era of Omics and Genome Editing -- 3. Gut Microbiome: Perspectives and Challenges in Human Health -- 4. Probiotics – A Healthy Treasure -- 5. Different Generations of Probiotics: An Effective Way to Restore Gut Homeostasis -- 6. Application Of Potential Microbial Biotechnology for Sustainable Human Health -- Section II: Emerging Technologies in Gut Microbiome Research -- 7. Emerging Technologies and Current Advances in Human Bacteriome Research -- 8. Emerging Microbial Technologies: Mitigating Challenges to Humanity -- 9. Modern Tools of Genome Engineering and Their Applications -- 10. Emerging Technologies to Investigate the Potential of Gut Microbiota in Human Health -- 11. Tools and Techniques for Exploring Hidden Microorganisms: A Potential Future of Human Health Diagnosis -- 12. Crispr-Cas Fundamentals and Advancements in Translational Biotechnology” -- Section III: Gut Microbiome and Metabolic Disorders -- 13. Microbiome and Human Health: From Dysbiosis to Therapeutic Interventions -- 14. Gut Microbiota and Its Role in Human Metabolic Disorders -- 15. Influence Of the Gut Microbiome on Cardiovascular Health and Hypertension -- 16. Role Of Microbiome in Reproductive Health: An Expanding Dimension -- 17. Role Of Bacteriocins in Modulation of Microbiome in Human Diseases -- 18. Emerging Role of Gut Microbiome in Cancer Immunotherapy -- 19. Microbial Secondary Metabolites: Targetting Tumors and Associated Challenges -- 20. Bacteria And Bacteria-Based Products in Cancer Therapy: Current Status and Future Advances -- 21. Communication With Gut Microbiota: An Emerging Strategy to Predict and Prevent Cancer -- 22. Insights in the Cross-Talk Between Microbiota-Gut-Brain Axis: A Focus On Alzheimers’s Disease -- Section IV: Association of Phages and Fungi with Gut Microbiome -- 23. Fungi As a Treasure Trove of Bioactive Compounds for Human Health -- 24. Reminiscing Phages in The Era of Superbugs -- 25. The Potential of Bacteriophages in Treating Covid-19 Associated Secondary Infections -- Section V: Diverse Roles of Microbiome -- 26. Role Of Microbes in Production of Vaccines -- 27. Microbial Induced Calcite Precipitation Approach Towards Sustainable Development -- 28. Microbial Functional Foods and Nutraceuticals -- 29. Synthesis of Nanoparticles by Microbes -- 30. Microbial Biopharmaceuticals in Urolithiasis Management and Treatment -- 31. Use Of Yeast In The Welfare Of Human and Their Applications -- 32. Photoautotrophic Microbes with Potential for A Super Health Food On This Planet -- 33 Autopsy and COVID-19 -- 34 COVID and their Impacts on Aquatic Systems: Is it a Solution for Environmental Resilience? .
    Abstract: This book examines the role of human microbiome in human health and diseases. The initial chapters present tools for genetic manipulation of gut microbiota and the therapeutic applications of engineered microbiota. They discuss the interaction between human microbiota and host in defining the prominent role of microbes in the development and progression of major human diseases. The book also summarizes the current applications and trends for the development, production and analytical characterization of recombinant therapeutic proteins in microbial systems. It also reviews the role of microbes in the production of vaccines and antibiotics. Further, the book presents bacterial products, including proteins, enzymes, immunotoxins and secondary metabolites, that target cancer cells and cause tumour regression. The chapters also discuss the critical role of gut microbiota dysbiosis in the pathogenesis of autoimmune disease and in bowel-related diseases. Towards the end, the book explores the role of intestinal microbiota in metabolic health and the pathogenesis of common metabolic disorders. It presents state-of-the-art insights into important aspects of United Nations—Sustainable Developmental Goal 3.
    Type of Medium: Online Resource
    Pages: XXII, 713 p. 55 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819931262
    DDC: 579
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology reviews 19 (1996), S. 0 
    ISSN: 1574-6976
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract: Hexachlorocyclohexane (HCH) is an organochlorine insecticide which has been banned in technologically advanced countries. However, it is still in use in tropical countries for mosquito control and thus new areas continue to be contaminated. Anaerobic degradation of HCH isomers have been well documented but until recently there have been only a few reports on aerobic microbial degradation of HCH isomers. The isolation of these microbes made it possible to design experiments for the cloning of the catabolic genes responsible for degradation. We review the microbial degradation of HCH isomers coupled with the genetic manipulations of the catabolic genes. The first part discusses the persistence of residues in the environment and microbial degradation while the second part gives an account of the genetic manipulations of catabolic genes involved in the degradation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 42 (1989), S. 45-49 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 16 (1987), S. 753-757 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Saccharomyces cerevisiae accumulated DDT, fenitrothion, and chlorpyrifos rapidly from yeast glucose medium. The maximum concentrations of DDT, fenitrothion, and chlorpyrifos accumulated were 8,253, 18,960 and 11,579 μg/g (dry wt), respectively. The pattern of accumulation was similar for all insecticides. The bioconcentration factor was inversely proportional to insecticide solubilities.Saccharomyces metabolized the three insecticides, but only two metabolites of DDT (DDD and DDE) were identified. Protoplast cultures were more sensitive to DDT and fenitrothion compared to normal cultures but were less sensitive to chlorpyrifos. Both the normal and protoplast cultures recovered from the toxic effect after 24 hr.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 9 (1980), S. 163-170 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The effect of DDT on growth and DNA synthesis inStylonychia notophora was investigated. DDT at a concentration of one ppm did not alter the cell population growth and the morphology of the organisms. However, 50 and 100 ppm DDT inhibited growth and cell division. Continuous treatment of the organisms with 100 ppm DDT produced several nuclear abnormalities. Cells treated with 100 ppm DDT in G1 did not enter S-phase while DNA synthesis was blocked in those cells treated in S-phase.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 42 (1988), S. 57-65 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The concentration of organochlorine insecticides/metabolites, namely, lindane, heptachlor, aldrin, p,p′-DDL, p,p′-DDD, and p,p′-DDT were determined in water samples taken from two lakes, Jalmahal and Mahalon, from June 1985 to July 1986. These lakes are contaminated with moderate to high level of residues of different insecticides. In Mahalon lake the residues were highest (6.6 μg L−1) during October 1985 whereas in Jalmahal lake they were highest (9.6 μg L−1) in September 1985. In both lakes, residues of DDT exceeded the recommended limit for water quality criteria. Lindane was found in most of the samples but in lower quantities. Aldrin was the second most common residue in these lakes.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 18 (1982), S. 441-447 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Tetrahymena pyriformis readily accumulated DDT and its metabolites from the medium initially containing 1 ppm of each compound. These compounds were accumulated in a decreasing order of DDD, DDE, o,p′-DDT, DDMU, and p,p′-DDT. DDT was metabolized to DDE, o,p′-DDT, and DDMU. DDD was metabolized to DDMU whereas o,p′-DDT, DDE and DDMU were not metabolized. When the organisms were transferred to toxicant free medium excretion of p,p′-DDT and its metabolite occurred in two phases: (a) rapid phase of elimination which was completed during the first 3 h and (b) slow phase of elimination which continued for another 21 h. The implications of these results are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 40 (1988), S. 345-349 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A ciliate protozoan, Tetrahymenapyriformis was exposed to three insecticides, dieldrin, dimethoate, and permethrin for 12 hr to study the uptake and bioconcentration potential. Ciliates concentrated 922, 3547, and 1056 gg g−1 dry wt. over an initial concentration of 1 gg mL−1 of dieldrin, dimethoate, and permethrin, respectively. The highest bioconcentration factor for three insecticides was 2095, 3547, and 1110, respectively. It is suggested that if levels in the environment reach 1 gg mL−1 the chief effects would be reduction of cell population, and accumulation of the toxicants by ciliates. Accumulation of insecticides by ciliates would permit the toxicants to enter aquatic food chains. Thus the compounds could exert toxic effects at higher trophic levels.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    BioEssays 16 (1994), S. 211-216 
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Rifamycin is a clinically useful macrolide antibiotic produced by the gram positive bacterium. Amycolatopsis mediterranei. This antibiotic is primarily used against Mycobacterium tuberculosis and Mycobacterium leprae, causative agents of tuberculosis and leprosy, respectively. In these bacteria, rifamycin treatment specifically inhibits the initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Apart from its activity against the bacteria, rifamycin has also been reported to inhibit reverse transcriptase (RT) of certain RNA viruses. Recently, rifamycin derivatives have been dis-covered that are effective against Mycobacterium avium, which is associated with the AIDS complex. Consequently, the importance of and demand for rifamycin has increased tremendously, the world over. In this article, recent trends in rifamycin research and accessability of recombinant DNA techniques to increase rifamycin production are reviewed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2022-05-25
    Description: © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 6 (2016): 25527, doi:10.1038/srep25527.
    Description: Despite having serious clinical manifestations, Cellulosimicrobium cellulans remain under-reported with only three genome sequences available at the time of writing. Genome sequences of C. cellulans LMG16121, C. cellulans J36 and Cellulosimicrobium sp. strain MM were used to determine distribution of pathogenicity islands (PAIs) across C. cellulans, which revealed 49 potential marker genes with known association to human infections, e.g. Fic and VbhA toxin-antitoxin system. Oligonucleotide composition-based analysis of orthologous proteins (n = 791) across three genomes revealed significant negative correlation (P 〈 0.05) between frequency of optimal codons (Fopt) and gene G+C content, highlighting the G+C-biased gene conversion (gBGC) effect across Cellulosimicrobium strains. Bayesian molecular-clock analysis performed on three virulent PAI proteins (Fic; D-alanyl-D-alanine-carboxypeptidase; transposase) dated the divergence event at 300 million years ago from the most common recent ancestor. Synteny-based annotation of hypothetical proteins highlighted gene transfers from non-pathogenic bacteria as a key factor in the evolution of PAIs. Additonally, deciphering the metagenomic islands using strain MM’s genome with environmental data from the site of isolation (hot-spring biofilm) revealed (an)aerobic respiration as population segregation factor across the in situ cohorts. Using reference genomes and metagenomic data, our results highlight the emergence and evolution of PAIs in the genus Cellulosimicrobium.
    Description: The authors acknowledge funds from Department of Biotechnology (DBT) and National Bureau of Agriculturally Important Microorganisms (NBAIM). AS gratefully acknowledge National Bureau of Agriculturally Important Microorganisms (NBAIM) for providing research fellowship.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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