Publication Date:
1985-06-14
Description:
Eukaryotic microorganisms, as well as higher animals and plants, display many autonomous physiological and biochemical rhythmicities having periods approximating 24 hours. In an attempt to determine the nature of the timing mechanisms that are responsible for these circadian periodicities, two primary operational assumptions were postulated. Both the perturbation of a putative element of a circadian clock within its normal oscillatory range and the direct activation as well as the inhibition of such an element should yield a phase shift of an overt rhythm generated by the underlying oscillator. Results of experiments conducted in the flagellate Euglena suggest that nicotinamide adenine dinucleotide (NAD+), the mitochondrial Ca2+-transport system, Ca2+, calmodulin, NAD+ kinase, and NADP+ phosphatase represent clock "gears" that, in ensemble, might constitute a self-sustained circadian oscillating loop in this and other organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goto, K -- Laval-Martin, D L -- Edmunds, L N Jr -- 2S07RR05736/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 14;228(4705):1284-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988128" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Biological Clocks
;
Biological Transport
;
Calcium/physiology
;
Calmodulin/physiology
;
*Circadian Rhythm
;
Euglena/*physiology
;
Mitochondria/physiology
;
NAD/physiology
;
NADP/physiology
;
Nucleotidases/*physiology
;
Oxidation-Reduction
;
Phosphotransferases/metabolism
;
*Phosphotransferases (Alcohol Group Acceptor)
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
