Publication Date:
1999-09-18
Description:
A 22-kilodalton protein was isolated from the submandibular (mental) gland of the male terrestrial salamander, Plethodon jordani (family: Plethodontidae). This proteinaceous pheromone, termed plethodontid receptivity factor (PRF), was experimentally delivered to the female during courtship and shown to increase female receptivity. In most plethodontid salamanders, ovulation occurs weeks or months after insemination, so the pheromone-induced change in receptivity is the only known function of PRF. The messenger RNAs corresponding to isoforms of PRF were transcribed into complementary DNA, cloned, sequenced, and shown to have homology with cytokines of the interleukin-6 family. Pheromone activity would represent a previously unrecognized function for cytokines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rollmann, S M -- Houck, L D -- Feldhoff, R C -- New York, N.Y. -- Science. 1999 Sep 17;285(5435):1907-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ecology and Evolution, University of Chicago, 1101 East 57 Street, Chicago, IL 60637, USA. Department of Zoology, Oregon State University, 3029 Cordley Hall, Corvallis, OR 97331, USA. smrollma@midway.uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10489368" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Female
;
Humans
;
Male
;
Molecular Sequence Data
;
Sequence Homology, Amino Acid
;
Sex Attractants/*analysis/genetics/physiology
;
Sexual Behavior, Animal/*physiology
;
Urodela
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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