Publication Date:
1980-11-28
Description:
Three of 21 newborn baboons injected intraocularly with human adenovirus type 12 developed an intravitreal mass 12 to 36 months later. Two of the masses were indistinguishable from human retinoblastoma, a retinal tumor that afflicts children. To our knowledge this is the first time a retinoblastoma-like tumor has been induced experimentally by adenovirus type 12 in a nonhuman primate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukai, N -- Kalter, S S -- Cummins, L B -- Matthews, V A -- Nishida, T -- Nakajima, T -- EY-03170/EY/NEI NIH HHS/ -- RR-00036/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1023-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434012" target="_blank"〉PubMed〈/a〉
Keywords:
*Adenoviruses, Human
;
Animals
;
Cell Transformation, Neoplastic/pathology
;
Cell Transformation, Viral
;
*Disease Models, Animal
;
Eye Neoplasms/*microbiology
;
Neoplasms, Experimental/microbiology
;
Papio
;
Retinoblastoma/*microbiology/pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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