Electronic Resource
[s.l.]
:
Nature Publishing Group
Nature structural & molecular biology
12 (2005), S. 624-625
ISSN:
1545-9985
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Medicine
Notes:
[Auszug] Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-Å crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/nsmb956
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