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  • 1
    Keywords: Medical microbiology. ; Microbial genetics. ; Microbiology. ; Internal medicine. ; Medical Microbiology. ; Microbial Genetics. ; Microbiology. ; Internal Medicine.
    Description / Table of Contents: Chapter 1. Antimicrobial Resistance Traits and Molecular Mechanisms of Resistance in Bacterial Pathogens -- Chapter 2. Bacterial multidrug tolerance and persisters: Understanding the Mechanisms, Clinical implications and treatment strategies -- Chapter 3. Microbial Pathogenesis: Mechanism and recent updates on microbial diversity of pathogens -- Chapter 4. Pseudomonas aeruginosa: Pathogenic adapter bacteria -- Chapter 5. Impact of antibiotic resistance of bacteria in biofilms, microbial fuel cell: Confronting the dark box for global health threat -- Chapter 6. Plant Secondary Metabolites for Tackling Antimicrobial Resistance: A Pharmacological Perspective -- Chapter 7. Can nanoparticles help in the battle against drug resistant bacterial infections in “post-antibiotic era”? -- Chapter 8. Precise Sequence-specific Antimicrobials Based on CRISPR: Towards Prevailing Over Bacterial Antibiotic Resistance -- Chapter 9. Antibiotic resistant Klebsiella pneumoniae and targeted therapy. Chapter 10. Plant associated endophytic fungi and its secondary metabolites against drug resistant pathogenic microbes -- Chapter 11. Antimicrobial peptides as effective agents against drug resistant pathogens -- Chapter 12. Essential oils for combating antimicrobial resistance -- Chapter 13. Antimicrobial resistance and medicinal plant products as potential alternatives to antibiotics in animal husbandry -- Chapter 14. Recent updates on bacterial secondary metabolites to overcome antibiotic-resistance in Gram-negative superbugs: Encouragement or discontinuation? -- Chapter 15. Plant essential oils for combating antimicrobial resistance via re-potentiating the fading antibiotic arsenal -- Chapter 16. Bacterial Drug Efflux Pump Inhibitors from Plants -- Chapter 17. Anti-quorum sensing agents from natural sources -- Chapter 18. Plant based plasmid curing agents for combating antimicrobial resistance -- Chapter 19. Natural product as efflux pump inhibitors against MRSA efflux pumps: An Update.
    Abstract: Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials. This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.
    Type of Medium: Online Resource
    Pages: XII, 605 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811631207
    DDC: 616.9041
    Language: English
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  • 2
    Keywords: Plant biotechnology. ; Nanotechnology. ; Biotechnology. ; Medical microbiology. ; Plant Biotechnology. ; Nanotechnology. ; Biotechnology. ; Medical Microbiology.
    Description / Table of Contents: 1.The History of Antibiotics Illumes the Future of Antimicrobial Peptides Administered Through Nano-Systems -- 2.Current approaches and prospects of nanomaterials in rapid diagnosis of antimicrobial resistance -- 3.Nanomaterials-mediated delivery of antimicrobial agents ‘The Nanocarriers’ -- 4.Nanoparticle functionalization: Approaches and applications -- 5.Nano-adjuvants as effective next-generation antimicrobial agents -- 6.Limiting antibiotic-resistant bacteria using multifunctional nanomaterials -- 7.Microbial resistance mechanisms and potential of metal-organic framework in mitigation thereof -- 8.Silver-based Nano-Formulations for Treating Antibiotic-Resistant Microbial Strains -- 9.Gold Nanoparticles: A Lethal Nanoweapon against Multidrug Resistant Bacteria -- 10.Antimicrobial Potentials of Zinc and Iron Oxide Nanoparticles -- 11.Carbon Nanostructures for Fighting Antimicrobial Resistant Bacteria -- 12.Nano-formulations against Multidrug Resistant Members of ESKAPE pathogens.
    Abstract: Antibiotics, the backbone of modern clinical-medicine, are facing serious challenges from emerging antimicrobial-resistance (AMR), a complicated phenomenon expanding in bacterial species, from nosocomial to community origins, where microbes are no longer sensitive to a range of commonly used antibiotics. AMR has exploded in recent years and is posing a serious threat to human health and survival. This necessitates novel and effective ways of diagnosis, drug-delivery, and treatment; nanotechnology and advanced nanomaterials are hailed as a potent solution in containing AMR. The main thrust of this volume is to explain the most current research on the central theme of potential use of nano-approaches for diagnosis, detection, drug-delivery and as antimicrobial agents against drug-resistant pathogenic microbes. This book provides an integrated blend of basic and advanced information for students, scholars, scientists and practitioners, interested or already engaged in research in these areas. We have brought together leading international authors to present and highlight various aspects of nanotechnology in combating AMR in WHO-prioritized microbes. Topics range from advances in nanomaterial synthesis, characterization, functionalization and improvisation, as well as applications in sensing, diagnosis of AMR, and their therapeutic and drug-delivery potential against MDR and XDR microbial phenotypes.
    Type of Medium: Online Resource
    Pages: X, 415 p. 57 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031102202
    Series Statement: Nanotechnology in the Life Sciences,
    DDC: 631.52
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 59 (1987), S. 842-846 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The major goal of these studies is to more fully assess the polymorphism of the hemopoietic histocompatibility (Hh) genetic system. H-2 homozygosity is required for optimal immunogenicity of bone marrow cell (BMC) grafts, and “hybrid resistance” to grafts of parental strain BMC by irradiated H-2 heterozygous F1 hybrid mice suggests that Hh-1 antigens are inherited recessively. The Hh-1 antigens are also expressed on other normal hematopoietic cells and lymphoid tumors, and natural killer cells are the effectors which mediate the elimination of BMC grafts in an Hh-specific manner. Previous studies have demonstrated three different antigens mapping to the Hh-1 locus near H-2D. We test the expression of Hh-1 on BMC of all nonrecombinant H-2 haplotypes of independent origin and H-2 j , a presumed natural recombinant. Hh-1 typing is based on the pattern of growth and rejection in a panel of hosts. F1 hybrids with H-2 b , H-2 d , and H-2 k are produced and used as donors and hosts to confirm the phenotype. Grafts of b-, d-, and j-haplotype marrow serve as prototypical examples of determinants that are provisionally designated as 1, 2, and 3, respectively. We describe a new determinant, 4, in the k haplotype. It is non-codominantly expressed, maps to H-2D, and is also expressed on H-2b BMC. NZW, H-2Z grafts exhibit a phenotype similar to k, but express a unique determinant 5 which can be distinguished from determinant 4. This additional determinant is also expressed by the b haplotype. The d, f, and p haplotypes all express determinant 2, and grafts of j-haplotype marrow are found to express determinants 2 and 5 in addition to determinant 3. The q and r haplotypes are null for all known determinants. Finally, we describe a phenotype which is a new combination of previously described determinants: s-haplotype grafts express determinants 1, 2, and 4. The polymorphism of Hh-1 detected thus far consists of seven alleles which are combinations of five distinct determinants.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 10 (1971), S. 289-293 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 28 (1989), S. 1664-1669 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 30 (1991), S. 1139-1141 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 276 (1976), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 345-347 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Friend leukaemia virus complex (FV) induces erythro-leukaemia and causes severe immunosuppression in genetically susceptible adult mice7. FV mediates immunosuppression, at least in an in vitro model, by activating T suppressor cells8,9. The T suppressor cells prevent T and bursa ...
    Type of Medium: Electronic Resource
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  • 10
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