ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The direct C mercuration in the 5 position of 1-acetyluracil by means of mercury (II) trifluoroacetate in anhydrous acetonitrile is described. The intermediately formed 1-acetyl-5-trifluoroacetoxymercuriuracil, without isolation, was subjected to symmetrization by the action of potassium iodide. The acetyl groups were then readily split out by the action of water. The resulting 5,5′-mercuribisuracil (50% yield) forms 5-iodo- or a 5-chlorouracil in 93% or 72% yields, respectively, under the influence of an aqueous KI3 solution or excess pure liquid S2Cl2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00506675
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