ISSN:
1573-9171
Schlagwort(e):
electrosynthesis
;
alkylation
;
2(1H)-thiopyridone
;
thieno[2,3-b]pyridine
;
disulfide
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract A series of substituted 2-alkyl(aryl-, hetaryl-)thiopyridines was prepared by cathodic electrolysis of thiols in the presence of 2-chloro-3-cyano-4-methoxymethyl-6-methylpyridine or 4-chloro-6-methyl-3-oxo-1H-furo[3,4-c]pyridine. The reaction of 3-cyano-4-methoxymethyl-6-methyl-2(1H)-thiopyridone with alkyl halides in the presence of KOH is regioselective and leads toS-alkyl derivatives. The advantages of electrosynthesis for the preparation of 2-alkylthiopyridines fused with 2(5H)-furanone and of 3-aminothieno [2,3-b]pyridines is demonstrated.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00700178
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