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  • 1
    Electronic Resource
    Electronic Resource
    Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 414 (2001), S. 638-643 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/414638a
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  • 2
    Electronic Resource
    Electronic Resource
    Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 402 (1999), S. 544-547 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Asymmetric cell division generates daughter cells with different developmental fates from progenitor cells that contain localized determinants. During this division, the asymmetric localization of cell-fate determinants and the orientation of the mitotic spindle must be precisely coordinated. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/990128
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  • 3
    Electronic Resource
    Electronic Resource
    Defective ommatidial cell assembly leads to defective morphogenesis: a phenotypic analysis of the E(spl) D mutation of Drosophila melanogaster (1990)
    Springer
    Development genes and evolution 198 (1990), S. 286-294 
    Details
    ISSN: 1432-041X
    Keywords: Compound eye morphogenesis ; Enhancer of split ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The spl mutation of the N gene causes, among other phenotypic traits, the lack of a few ommatidia, roughness and a general reduction in the size of the compound eye; these defects are drastically enhanced by the dominant mutation E(spl) D. We have studied cellular and developmental aspects of the phenotypic interaction between spl and E(spl) D. We found that the initial clustering of photoreceptor cells is affected in eye imaginal discs of spl larvae causing the defects visible in the adult eye. The degree of disorganization of the spl/Y; E(spl) D/ + eye disc is much higher, only a few photoreceptor cells are able to group with representatives of the other cell types and differentiate normally. BrdU incorporation shows that the proliferation pattern of the spl/Y; E(spl) D/ + disc cells during the third instar is normal. Abundant cell death occurs posteriorly in the mutant discs, which accounts for their small size. Finally, we found that in the eye imaginal disc the transcription of m8, the E(spl) gene, responsible for the enhancement of the spl phenotype caused by the E(spl) D mutation, is restricted to the morphogenetic furrow, where the ommatidial cells start grouping with each other to take on their future developmental fates; the m8 transcription rate is highly increased in E(spl) D eye discs. All these observations indicate that the assembly of the ommatidial cells is affected in the spl/Y; E(spl) D/ + disc and that the other abnormalities are morphogenetic consequences of the defective cell grouping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00377395
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  • 4
    Electronic Resource
    Electronic Resource
    Phenotypic and developmental analysis of mutations at thecrumbs locus, a gene required for the development of epithelia inDrosophila melanogaster (1990)
    Springer
    Development genes and evolution 199 (1990), S. 189-206 
    Details
    ISSN: 1432-041X
    Keywords: Crumbs ; Drosophila ; Epithelial development ; Cell death ; Cell polarity ; Non autonomous behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The genecrumbs (crb) ofDrosophila melanogaster provides an essential function for the embryonic development of ectodermally derived epithelia. Complete loss of function alleles of thecrb gene are recessive embryonic lethals and lead to a disorganization of the primordia of these epithelia, followed by cell death in some tissues. Incrb mutant embryos, different organs are affected to a different extent. Some tissues die almost completely (as the epidermis, the atrium and the pharynx) while others partially survive and conserve their basic epithelial structure (as the tracheal system, the oesophagus, the proventriculus, the salivary glands, the hindgut and the Malpighian tubules). Degeneration is first visible at stage 11 and continues successively throughout development. There is evidence that the loss of epithelial cell polarity may be the cause for the degeneration of these tissues, suggesting that thecrb gene product is involved in stabilizing the apico-basal polarity of epithelial cells. As previously shown, thecrb protein is specifically expressed on the apical side of embryonic epithelia in a reticular pattern outlining the borders of the cells. Here we demonstrate that thecrb protein shows the same subcellular localization in epithelial cells of imaginal discs and in follicle cells, indicating a similar function ofcrb during the development of embryonic, imaginal and follicle epithelia. Clonal analysis experiments indicate that the genecrb is not cell-autonomous in its expression, suggesting that the gene product may act as a diffusible factor and may serve as a signal in a cell-cell communication process. This signal is thought to be required for the formation and/or maintenance of the cell and tissue structure of the respective epithelia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01682078
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  • 5
    Electronic Resource
    Electronic Resource
    A functional analysis of the genes Enhancer of split and HLH-m5 during early neurogenesis in Drosophila melanogaster (1993)
    Springer
    Development genes and evolution 203 (1993), S. 10-17 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila neurogenesis ; Helix-loop-helix protein ; Enhancer of split
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract To assess the functional domains of the proteins encoded by E(spl) and HLH-m5, two genes of the Enhancer of split complex [E(SPL)-C] of Drosophila melanogaster, a number of variants have been made by in vitro mutagenesis, transformed into the germ line of the wild-type, and genetically combined with a chromosomal deletion lacking four of the genes of the E(SPL)-C. All constructs used attenuated the neurogenic phenotype associated with this deletion. However, constructs encoding proteins with truncated carboxy-termini exibited in all cases a higher activity than constructs encoding the full length version of the protein. Neutralization of the basic domain severely reduced, but did not completely abolish the rescuing activity of E(spl), while proteins in which a proline residue within the basic domain had been changed to either threonine or asparagine were slightly less efficient in their rescuing activity than the corresponding wild-type versions. We discuss the possible significance of these results for the function of the protein domains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539885
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular organization of master mind, a neurogenic gene of Drosophila melanogaster (1987)
    Springer
    Molecular genetics and genomics 207 (1987), S. 374-384 
    Details
    ISSN: 1617-4623
    Keywords: master mind ; Molecular cloning ; Drosophila ; Neurogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The gene master mind (mam) is located in bands 50C23-D1 of the second chromosome of Drosophila melanogaster. mam is one of the neurogenic genes, whose function is necessary for a normal segregation of neural and epidermal lineages during embryonic development. Loss of function of any of the neurogenic genes results in a mis-routeing into neurogenesis of cells that normally would have given rise to epidermis. We describe here the molecular cloning of 198 kb of genomic DNA containing the mam gene. Ten different mam mutations (point mutants and chromosomal aberrations) have been mapped within 45 kb of the genomic walk. One of the mutations, an insertion of a P-element, was originally recovered from a dysgenic cross. Four different wild-type revertants of this mutation were characterized at the molecular level and, although modifications of the insertions were found, in no case was the transposon completely excised. An unusually high number of the repetitive opa sequence, and of an additional previously unknown element, which we have called N repeat, are scattered throughout the 45 kb where the mam mutations map. The functional significance of these repeats is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331604
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  • 7
    Electronic Resource
    Electronic Resource
    bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes (1994)
    Springer
    Molecular genetics and genomics 244 (1994), S. 465-473 
    Details
    ISSN: 1617-4623
    Keywords: Drosophila ; Enhancer of split ; Helix-loop-helix protein ; Neurogenesis ; Transcriptional repressors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract TheEnhancer of split complex [E(SPL)-C] ofDrosophila participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. It encodes seven proteins that belong to the basic helix-loop-helix (bHLH) family, six of which are expressed in very similar patterns in the neuroectoderm. Here we describe experiments aimed at unravelling the molecular basis of their function. We found that two products of the complex, HLH-M5 andEnhancer of split, are capable of binding as homo-and heterodimers to a sequence in the promoters of theEnhancer of split andachaete genes, called the N-box, which differs slightly from the consensus binding site (the E-box) for other bHLH proteins. In transient expression assays in cell culture, both proteins were found to attenuate the transcriptional activation mediated by the proneural bHLH proteinslethal of scute anddaughterless at theEnhancer of split promoter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583897
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  • 8
    Electronic Resource
    Electronic Resource
    Adherens junctions in the Drosophila embryo: The role of E-cadherin in their establishment and morphogenetic function (1996)
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 609-612 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The integrity of epithelia depends largely on specialised adhesive structures, the adherens junctions. Several of the components required for building these structures are highly conserved between vertebrates and insects (e.g. E-cadherin and α- and β-catenin), while others have so far been found only in invertebrates (e.g. crumbs). Two recent papers(1,2) show that the Drosophila E-cadherin is encoded by the gene shotgun. Phenotypic analyses of shotgun as well as armadillo (β-catenin) and crumbs mutants provide new insights into the mechanisms by which adherens junctions are built and, further, show that the requirement for E-cadherin largely depends on the morphogenetic activity of an epithelium.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950180802
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  • 9
    Electronic Resource
    Electronic Resource
    The molecular genetics of early neurogenesis in Drosophila melanogaster (1989)
    New York, NY : Wiley-Blackwell
    BioEssays 11 (1989), S. 95-100 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The extent of neurogenesis in Drosophila is under the control of the so-called neurogenic genes, named for their mutant phenotype of causing neural hyperplasia. Their wild-type products appear to be responsible for a signal chain that decides the fate of ectodermal cells in the embryo. Various kinds of data, from cell transplantation experiments as well as from genetic and molecular analyses, suggest that the proteins encoded by the genes Notch and Delta may act at the membrane of the signal-transmitting cells to provide a ligand to a still unknown receptor molecule; in contrast, the locus of Enhancer of split codes for several functions related to the transduction and further processing of the signal.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950110405
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  • 10
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    Cell Polarity from Cell Division (2007)
    Cell Press
    Details
    Publication Date: 2007-05-01
    Print ISSN: 1534-5807
    Electronic ISSN: 1878-1551
    Topics: Biology , Medicine
    Published by Cell Press
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