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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and Characterization of Novel Aromatic Poly(ether sulfone ketones) (1995)
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 916-921 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00108a018
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Substrate Texture on Superconducting Properties of YBCO Thick Films (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 124-126 (June 2007), p. 283-286 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: On nontextured substrates, YBCO superconducting thick films were fabricated using asimple screen-printing method, from Cu-free powders (Y2O3 and BaCO3). However, the films havepoor superconducting properties, such as the critical current density, Jc value due to the randomorientation of the films. In this work, we investigate the influence of substrate texture onsuperconducting properties of the film. The films screen-printed on the nontextured and textured Cusubstrates were heat-treated by 2-step procedure in air (980 °C 10 sec + 930 °C 90 sec) followed byoxygen annealing at 450 °C for 1 hr. We speculate that Cu ions diffusion from the textured Cusubstrates is still faster than Cu ions diffusion from the nontextured Cu substrates that CuO formedexcessively in the film deteriorates superconducting properties of the YBCO film
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.124-126.283.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 145-148 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Poly-L-lactic acid (PLLA) is a desirable and very attractive polymer for fabricatingporous scaffolds. As of now, a solvent casting method with organic solvents has been used inscaffold fabrication process. However, residual organic solvents in the scaffolds have the problemsof decreasing the effect of osteogenic induction due to the hindrance of bioceramic by polymersolution and it’s harmfulness in vivo. To avoid these disadvantages of scaffolds by organic solventcasting method, we developed a new method fabricating polymer (PLLA)/ceramic (β -TCP)composite scaffolds by baking method without using solvent, and then we tested properties ofscaffolds on animals. As the result, non-toxicity has been proved through animal experiment andnewly fabricated polymer/ceramic composites by a novel sintering method were induced rapid boneregeneration through enhancing the interaction of cells and a bone induction factor without any hostimmune response
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.145.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Mechano-Active Cartilage Tissue Engineering (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 49 (Oct. 2006), p. 189-196 
    Details
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: To engineer cartilaginous constructs with a mechano-active scaffold and dynamiccompression was performed for effective cartilage tissue engineering. Mechano-active scaffolds werefabricated from very elastic poly(L-lactide-co-ε-carprolactone)(5:5). The scaffolds with 85 %porosity and 300~500 μm pore size were prepared by a gel-pressing method. The scaffolds wereseeded with chondrocytes and the continuous compressive deformation of 5% strain was applied tocell-polymer constructs with 0.1Hz to evaluate for the effect of dynamic compression forregeneration of cartilage. Also, the chondrocytes-seeded constructs stimulated by the continuouscompressive deformation of 5% strain with 0.1Hz for 10 days and 24 days respectively wereimplanted in nude mice subcutaneously to investigate their biocompatibility and cartilage formation.From biochemical analyses, chondrogenic differentiation was sustained and enhanced significantlyand chondrial extracellular matrix was increased through mechanical stimulation. Histologicalanalysis showed that implants stimulated mechanically formed mature and well-developedcartilaginous tissue, as evidenced by chondrocytes within lacunae. Masson’s trichrome and SafraninO staining indicated an abundant accumulation of collagens and GAGs. Also, ECM in constructs wasstrongly immuno-stained with anti-rabbit collagen type II antibody. Consequently, the periodicapplication of dynamic compression can improve the quality of cartilaginous tissue formed in vitroand in vivo
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.49.189.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Cartilage Tissue Engineering using a Elastic Poly (L-Lactide-co-ε-Caprolactone) Scaffold (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 405-408 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Mechano-active scaffolds were fabricated from very elasticpoly(L-lactide-co-ε-carprolactone). The scaffolds with 80 % porosity and 300~500 μm pore sizewere prepared by a gel-pressing method. As a control group for elastic properties of polymerscaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds were seeded withchondrocytes and cultured to evaluate the effect of elastic properties of polymer scaffolds for thedifferentiation and the ECM secretion of chondrocytes. Also, the chondrocytes-seeded constructswere implanted in nude mice subcutaneously to investigate their biocompatibility and cartilageformation. From the biochemical analyses, chondrogenic differentiation was sustained andenhanced significantly and chondral extracellular matrix was increased through mechanicalstimulation of dynamic environment in the dynamic body systems. Histological analysis showedthat implants of PLCL constructs formed mature and well-developed cartilaginous tissue, asevidenced by chondrocytes within lacunae. Consequently, the elastic PLCL scaffolds could be usedto engineer cartilage in mechanically dynamic environments
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.405.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Mechano-Active Cartilage Tissue Engineering: The Effect of Dynamic Compressive Stimulation (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 409-412 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Mechano-active scaffolds were fabricated from very elasticpoly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bonemarrow stromal cells and the continuous compressive deformation was applied to cell-polymerconstructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously toevaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemicalanalyses, chondrogenic differentiation was sustained and enhanced significantly and chondralextracellular matrix was increased through mechanical stimulation. Histological analyses showedthat implants stimulated mechanically formed mature and well-developed cartilaginous tissue, asevidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodicapplication of dynamic compression can encourage bone marrow stromal cells to differentiation tochondrogenic lineage and to maintain their phenotypes
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.409.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    RGD Direct Conjugation Using Co-Solvent System to Increase Cell Attachment on Poly(lactide-co-glycolide) without Change in Hydrophilic/Hydrophobic Property (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 157-160 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We have developed a direct conjugation method of RGD (Arg-Gly-Asp) into polylactide(PLA) using co-solvent system, which showed high reaction yield compared to one solvent systempresumably due to good solubility of reactants. First, hydroxyl groups at the end of PLA werechanged into carboxyl acid by ring opening reaction of succinic anhydride. For a coupling reactionwith high solubility, RGD was dissolved in water and then PLA in dioxane was added into RGDsolution in the presence of 1-(3-dimenthylaminopropyl)3-ethylcarbodiimide hydrochloride (EDC).The conjugation of RGD was confirmed by 1H-NMR, GPC and elementary analysis. The RGDconjugated PLA (RGD-PLA) on poly(lactide-co-glycolide) (PLGA) film significantly increased thenumber of attached cells compared to PLGA without RGD-PLA, while it did not change staticcontact angle of PLGA. This result demonstrated this conjugation method would be a useful tool toincrease cell affinity of biomaterials without change in hydrophilic/hydrophobic property for tissueengineering applications
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.157.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Cartilaginous Tissue Formation with an Elastic PLCL Scaffold and Human Adipose Tissue-Derived Stromal Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 385-388 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In cartilage tissue engineering, as a cell source, adult stem cells are very attractive forclinical applications. Recent studies suggest that human adipose tissue-derived stromal cells (ASCs)have multilineage potential similar to bone marrow-derived stromal cells (BMSCs). ASCs areobtained from adipose tissue easily isolated by suction-assisted lipectomy in various body parts.Also, as one of major factors of cartilage tissue engineering, scaffolds have an important role incartilage formation. Poly(L-lactide-co-ε-carprolactone) scaffolds have physiological activity,biodegradability, high cell affinity, and mechano-activity. The object of this study is cartilaginoustissue formation using highly elastic PLCL scaffolds and ASCs in vitro and in vivo.Poly(L-lactide-co-ε-carprolactone) copolymers were synthesized from lactide and ε-carprolactonein the presence of stannous octoate as catalyst. The scaffolds with 85% porosity and 300-500μmpore size were fabricated by gel-pressing method. ASCs were seeded on scaffolds and cultured for21days in vitro. Cell/polymer constructs were characterized by reverse transcriptase-polymerasechain reaction for confirming differentiation to chondrocytes onto PLCL scaffolds. Also, forexamining cartilaginous tissue formation in vivo, ASCs seeded scaffolds which were inducedchondrogenesis for 2 weeks were implanted in nude mice subcutaneously for up to 8weeks.Histological studies showed that implants partially developed cartilaginous tissue within lacunae.And there was an accumulation of sulfated glycoaminoglycans. Immunohistochemical analysisrevealed that implants were positively stained for specific extracellular matrix. These resultsindicate that ASCs and PLCL scaffols could be used to cartilage tissue engineering
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.385.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    The Electrochemical Characteristics of Mg-Based Alloy Prepared by HT (Heat Treatment) and MG (Mechanical Grinding) for Nickel-Metal Hydride Secondary Batteries (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 475-479 (Jan. 2005), p. 2473-2476 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Mg2Ni powder was heated up to 880℃ which is higher than the melting point of Mg2Ni alloys (760℃) for 30 minutes and immediately cooled into water (14℃). And then, mechanical ball milling was conducted for 1,4,8,10,12,24 hours respectively. As milling time increased discharge capacity was increased to maximum of 700mAh/g at 12hours then decreased with increasing milling time. The best high rate dischargeability (HRD) characteristic also obtain at the 12 hours ball milling time. Therefore, the ball milling time could be shorten to 12 hours by heat treatment and rapid cooling. Praseodymium (0,0.2,0.5,0.7,1.0%Pr) was added to Mg2Ni alloys. These alloys were ground for 12 hours to investigate the improvement of cycle life. The cycle life was remarkably improved with increasing the amount of Pr. The best amount of Pr was 0.7 wt%
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/09/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.475-479.2473.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Tissue Engineered Bone Formation with Polymer/Ceramic Composites by Press-and-Baking Method (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 79-82 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel process was developed to fabricate polymer/ceramic composites for bonetissue engineering. The mixture of polylactic acid (PLA), calcium metaphosphate (CMP), and NaCl were compressed and subsequently heated. After dissolving the NaCl salts, porous biodegradable polymer/ceramic composite scaffolds were formed. The characteristics of the scaffolds were compared to those of scaffolds fabricated using a conventional solvent casting method, in terms of pore structure, pore size distribution, and mechanical properties. The scaffolds were seeded byosteoblasts and cultured in vitro or implanted into nude mice subcutaneously for up to 5 weeks. Cells were better grown to form tissue-like structures on CMP/PLA composites fabricated by the Press-and-Baking method. In addition, the alkaline phosphatase activity of and calcium deposition in the scaffolds explanted from mice were enhanced significantly for the scaffolds by Press-and-Baking compared to them by solvent casting. Taken together, these results suggest that CMP promote cell differentiation and proliferation via direct interaction with cells in the CMP/PLAcomposites. This novel PLA/CMP composite will be applicable for bone tissue engineering to support and cell differentiation and growth
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.79.pdf
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