Publication Date:
2014-02-28
Description:
Article RNA-guided endonucleases (RGENs) are promising tools for genome editing, although their limited activity poses a challenge. Here the authors use surrogate reporters to achieve enrichment of cells containing RGEN-induced mutations up to 11-fold, which could help facilitate the use of RGENs in biomedical research. Nature Communications doi: 10.1038/ncomms4378 Authors: Suresh Ramakrishna, Seung Woo Cho, Sojung Kim, Myungjae Song, Ramu Gopalappa, Jin-Soo Kim, Hyongbum Kim
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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