Publication Date:
2019
Description:
〈p〉The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)–producing regulatory B (IL-10〈sup〉+〈/sup〉 B〈sub〉reg〈/sub〉) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10〈sup〉+〈/sup〉 B〈sub〉reg〈/sub〉 cells are generated and maintained is still very limited. Here, we found that IL-10〈sup〉+〈/sup〉 B〈sub〉reg〈/sub〉 cells suppress the activation of IL-13–producing type 2 innate lymphoid cells (IL-13〈sup〉+〈/sup〉 ILC2s) in an IL-10–dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10〈sup〉+〈/sup〉 B〈sub〉reg〈/sub〉 cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10〈sup〉+〈/sup〉 B〈sub〉reg〈/sub〉 cells, and IL-13〈sup〉+〈/sup〉 ILC2s in CHS.〈/p〉
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General
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