ISSN:
1432-1041
Keywords:
Key words Cytochrome P450 IIIA
;
Maturation
;
Neonates; drug metabolism
;
6 βOHF/FF ratio
;
infants
;
CYP IIIA7
;
CYP IIIA3/4
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: Cytochrome P450 III (CYP III) has previously been demonstrated in vitro in fetal liver. Methods: A study was performed in 7 premature, 13 term neonates and 30 infants to assess whether or not maturation had any influence on CYP IIIA activity in children from birth to 1 year of age. A simple non invasive procedure was used (6 βOHF/FF concentration ratio in a morning spot urine sample). Results: The 6 βOHF/FF ratio was 7.2, 7.9 and 5.0 in premature and term neonates and infants, respectively. CYP IIIA activity is present at birth, with a 6 βOHF/FF ratio comparable to adults. Its activity seemed lower in infants. This might be due to the decrease in CYP IIIA7 activity during maturation after birth, which might be more rapid than the increase in CYP IIIA3/4 activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050162
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