ISSN:
1617-4623
Keywords:
Key words Circadian rhythm
;
Neurospora crassa
;
Temperature-sensitivity
;
un-18
;
Second-largest subunit of RNA polymerase I
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The period length of the circadian conidiation rhythm was examined in a mutant strain of Neurospora crassa, un-18, that is temperature sensitive for mycelial growth. The un-18 mutant showed a temperature-sensitive phenotype with respect to both mycelial growth and the period length of the conidiation rhythm. Below 22° C, the un-18 mutation did not affect the period length, but at temperatures between 22° C and 32° C, the period length of the un-18 mutant was ∼2 h longer than that of the wild-type strain. The un-18 + gene was cloned and was found to encode the second-largest subunit of RNA polymerase I, which is involved in the synthesis of rRNA. These results indicate that a defect in ribosome synthesis, which must result in a lower rate of protein synthesis, lengthens the period of the circadian conidiation rhythm in Neurospora.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004380050812
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