ISSN:
0368-1467
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
A pilot plant unit for continuous cultivation of hyphaeforming micro-organisms, providing for a uniform flow velocity in fermentations on suspension media with a massive growth of mycelium, is described. For the maintenance of aseptic conditions, over-pressre of air is maintained in the whole equipment. This equipment has been used for studies of the continuous biosynthesis of streptomycin. A three-stage fermentation proved the most advantageous. The first stage serves for multiplication of the inoculum; the second and third for the formation of the antibiotic. The system was maintained for 300-400 h with yields amounting to 2,000-2,500 u. of streptomycin/ml without any signs of contamination or degeneration of the growing culture.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jbmte.390010405
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