Publication Date:
1999-07-31
Description:
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brustle, O -- Jones, K N -- Learish, R D -- Karram, K -- Choudhary, K -- Wiestler, O D -- Duncan, I D -- McKay, R D -- NS33710/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 30;285(5428):754-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. brustle@uni-bonn.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10427001" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Astrocytes/*cytology
;
Brain/embryology/metabolism
;
Cell Differentiation
;
Cell Line
;
Cell Movement
;
Cerebral Ventricles/embryology/surgery
;
Diffuse Cerebral Sclerosis of Schilder/genetics/*therapy
;
Embryo, Mammalian/cytology
;
Growth Substances/pharmacology
;
Humans
;
Male
;
Mice
;
Myelin Basic Protein/biosynthesis
;
Myelin Proteolipid Protein/biosynthesis/genetics
;
Myelin Sheath/*physiology
;
Oligodendroglia/*cytology/metabolism/*transplantation/ultrastructure
;
Rats
;
Spinal Cord
;
Stem Cell Transplantation
;
Stem Cells/*cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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