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  • 1
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    Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-11-02
    Description: Detection and adaptation to cold temperature is crucial to survival. Cold sensing in the innocuous range of cold (〉10–15 °C) in the mammalian peripheral nervous system is thought to rely primarily on transient receptor potential (TRP) ion channels, most notably the menthol receptor, TRPM8. Here we report that TRP cation channel, subfamily C member 5 (TRPC5), but not TRPC1/TRPC5 heteromeric channels, are highly cold sensitive in the temperature range 37–25 °C. We found that TRPC5 is present in mouse and human sensory neurons of dorsal root ganglia, a substantial number of peripheral nerves including intraepithelial endings, and in the dorsal lamina of the spinal cord that receives sensory input from the skin, consistent with a potential TRPC5 function as an innocuous cold transducer in nociceptive and thermosensory nerve endings. Although deletion of TRPC5 in 129S1/SvImJ mice resulted in no temperature-sensitive behavioral changes, TRPM8 and/or other menthol-sensitive channels appear to underpin a much larger component of noxious cold sensing after TRPC5 deletion and a shift in mechanosensitive C-fiber subtypes. These findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Aligning science with politics and policy in HIV prevention (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hein, K -- New York, N.Y. -- Science. 1998 Jun 19;280(5371):1905-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medicine, National Academy of Sciences, Washington, DC 20418, USA. khein@nas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9669948" target="_blank"〉PubMed〈/a〉
    Keywords: Condoms ; Empirical Research ; Federal Government ; Female ; HIV Infections/epidemiology/*prevention & control ; Health Education ; *Health Policy ; Humans ; Internationality ; Male ; Needle-Exchange Programs ; *Politics ; Resource Allocation ; Risk-Taking ; Sexual Behavior ; Thailand/epidemiology ; United States/epidemiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging, and cancer. Here, we report a molecular link between Wnt/beta-catenin signaling and the expression of the telomerase subunit Tert. beta-Catenin-deficient mouse embryonic stem (ES) cells have short telomeres; conversely, ES cell expressing an activated form of beta-catenin (beta-cat(DeltaEx3/+)) have long telomeres. We show that beta-catenin regulates Tert expression through the interaction with Klf4, a core component of the pluripotency transcriptional network. beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells. We uncover a previously unknown link between the stem cell and oncogenic potential whereby beta-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffmeyer, Katrin -- Raggioli, Angelo -- Rudloff, Stefan -- Anton, Roman -- Hierholzer, Andreas -- Del Valle, Ignacio -- Hein, Kerstin -- Vogt, Riana -- Kemler, Rolf -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1549-54. doi: 10.1126/science.1218370.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723415" target="_blank"〉PubMed〈/a〉
    Keywords: Adult Stem Cells/*metabolism ; Animals ; Cell Line, Tumor ; Embryonic Stem Cells/*metabolism ; HEK293 Cells ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Mice ; Neoplasms/genetics/*metabolism ; Promoter Regions, Genetic ; RNA, Messenger/genetics/metabolism ; Telomerase/*genetics/metabolism ; Telomere/metabolism/ultrastructure ; Telomere Homeostasis ; Transcription Initiation Site ; Wnt Proteins/metabolism ; *Wnt Signaling Pathway ; beta Catenin/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Substrate Selective Catalysis by Rhodium Metallohosts (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 11906-11913 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00153a012
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  • 5
    Electronic Resource
    Electronic Resource
    The geology and genesis of the Tarcoola gold deposits, South Australia (1994)
    Springer
    Mineralium deposita 29 (1994), S. 224-236 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Tarcoola goldfield is located in the Gawler Craton in northwestern Eyre Peninsula, South Australia. The gold deposits are hosted in the Middle Proterozoic Tarcoola Formation, comprised of the fluviatile Peela Coglomerate Member, the shallow marine Fabian Quartzite Member, and the marine Sullivan Shale Member. Mineralization in the goldfield consists of north-northeast to north-northwest trending gold-bearing quartz veins with associated hematite, pyrite, arsenopyrite, sphalerite, chalcopyrite, galena, electrum and gold. Adamellite in contact with the Tarcoola Formation has previously been included in the Middle Proterozoic Hiltaba Suite granitoids, on the basis of an apparent intrusive relationship with the Tarcoola Formation, and the gold-quartz veins were interpreted as being genetically related to the cooling pluton. However, detailed field and petrographic studies have demonstrated that the contact between the Tarcoola Formation and adamellite is a nonconformity. Hence, there is no genetic relationship between the mineralization and the adamellite. Oxygen isotope data indicate that an oreforming fluid, derived from convective circulation of meteoric or seawater, or from formation water, underwent isotope exchange with sediments of the Tarcoola Formation. A magmatic heat source for the hydrothermal system is suggested by the presence of intrusive igneous rocks, including dykes of aplite, quartz monzonite and microdiorite. Sulphur isotope characteristics of the mineralization can be explained by reduction of seawater sulphate or dissolution of disseminated sulphides in the sedimentary sequence. Metals were probably derived from rocks of the Tarcoola Formation. A complex paragenetic sequence involved deposition of minerals in several stages separated by episodes of fracturing. Fluid inclusions in quartz and fluorite show that deposition took place over a temperature range of about 340° to 110°C from a low salinity fluid. Analyses of chlorite coexisting with sulphide minerals suggest deposition of sulphides from about 300° to 170°C. Gold was transported as Au(HS) 2 − and deposition appears to have coincided with a sudden decrease in fO2 at around 260° to 250 °C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206865
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  • 6
    Electronic Resource
    Electronic Resource
    Possible effects of photomultiplier-afterpulses on scintillation counter measurements
    Amsterdam : Elsevier
    Nuclear Instruments and Methods 84 (1970), S. 297-300 
    Details
    ISSN: 0029-554X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0029-554X(70)90276-4
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  • 7
    Electronic Resource
    Electronic Resource
    Kieselgel-Dunnschichtchromatographie von Flavonoiden
    Amsterdam : Elsevier
    Journal of Chromatography A 13 (1964), S. 235-237 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)95099-X
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  • 8
    Electronic Resource
    Electronic Resource
    Molecular analysis and mapping of two genes encoding maize glutathione S-transferases (GST I and GST II) (1995)
    Springer
    Molecular genetics and genomics 248 (1995), S. 535-539 
    Details
    ISSN: 1617-4623
    Keywords: Glutathione S-transferase ; Maize ; Gene expression ; Mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Maize glutathione S-transferase (GST) isozymes are encoded by a gene family comprising at least five genes, three of which (Gst I, II andIII) have recently been isolated and sequenced. The enzymes are active as homo or heterodimers and exhibit intraspecific polymorphism including a “null” variant for the two major isoforms expressed in roots. Northern blot analyses performed on total root RNA from “null” and “plus” genotypes, usingGst I- andGst II-specific probes, indicated that theGst I gene controls the expression of the two major GST isoforms expressed in roots.Gst I andGst II were mapped by RFLP analysis using an F2 population of 149 individuals previously characterized.Gst I was localized on the long arm of chromosome 8, while two putativeGst II loci were mapped to chromosomes 8 (70 cM fromGst I) and 10, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02423448
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  • 9
    Electronic Resource
    Electronic Resource
    Licht- und elektronenmikroskopische Untersuchungen an der Basalplatte der reifen menschlichen Plazenta (1971)
    Springer
    Cell & tissue research 122 (1971), S. 323-349 
    Details
    ISSN: 1432-0878
    Keywords: Human placenta ; Basal plate ; Trophoblast cells ; Decidua basalis ; Separation of the placenta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung In der Basalplatte der reifen menschlichen Plazenta lassen sich elektronenmikroskopisch verschiedene Arten von Trophoblastzellen (großer basaler (a), klarer (b), spongiotrophoblastähnlicher (c) Cytotrophoblast; Riesenzellen des Cyto- und Syncytiotrophoblasten) und verschiedene Typen von Deziduazellen (große Deziduazelle mit gut bzw. wenig differenziertem Cytoplasma, kleine Deziduazelle, undifferenzierte Stromazelle) nachweisen; ihr Feinbau wird eingehend beschrieben. Die Zellen sind in verschiedenen Schichten angeordnet und teilweise durch Fibrinoidablagerungen voneinander getrennt. Das Nitabuchsche Fibrinoid bildet jedoch keine dichte Grenze zwischen mütterlichen (Dezidua-) und fetalen (Trophoblast-) Zellen. In der Durchdringungszone liegen daher Zellen verschiedener Herkunft unmittelbar nebeneinander. — Die großen Deziduazellen weisen am Schwangerschaftsende keine strukturellen Äquivalente größerer Stoffwechselleistungen auf. Die kleinen Deziduazellen sind offenbar zu einer verstärkten Pinocytose befähigt. Einige der Deziduazelltypen dürften verschiedenen Stadien einer Entwicklungsreihe entsprechen. — Die große basale Cytotrophoblastzelle kommt aufgrund ihrer Ultrastruktur (viel rauhes ER, Golgiapparat, Sekretgranula) als möglicher Ort für die Synthese von Proteohormonen (z.B. HCG) in Frage. Ob und gegebenenfalls welche Aufgaben den anderen Trophoblastzellen der Basalplatte zukommen, kann morphologisch allein nicht entschieden werden. — Das Deziduagewebe hat eine prinzipielle Bedeutung für die spontane Lösung der Plazenta. Es werden einige morphologische Gesichtspunkte diskutiert, die für das Verständnis des Lösungsvorgangs von Bedeutung sein könnten.
    Notes: Summary By means of electron microscopy different types of trophoblast cells—large basal cytotrophoblast cell, clear cell, spongiotrophoblast-like cell, giant cells deriving from the syncytio- and cytotrophoblast—and different forms of decidual cells—large decidual cell with well or poorly organized cytoplasm, small decidual cell, undifferentiated stromal cell—can be distinguished in the basal plate of the full-term human placenta. The morphological characteristics of all these cells mentioned are described. All cells of the basal plate are arranged in different layers and partially separated from each other by fibrinoid. The so-called fibrinoid of Nitabuch does not form a dense border between fetal and maternal tissue. In the junctional zone, therefore, cells of different origin are in intimate contact.—The large and poorly organized decidual cells show no signs of a higher metabolism. The small decidual cells, however, are characterized by pinocytosis. A relationship exists between the poorly and the well organized large decidual cells. This seems to be true, too, for the small decidual cells and the undifferentiated stromal cells.—The large basal cytotrophoblast cells provided with rough ER, Golgi apparatus and secretory granules are considered to be a possible site of synthesis for placental proteohormones (e.g. HCG). The other types of basal trophoblast cells mentioned above may have some special functions during pregnancy.—The decidua basalis plays a basic role in the separation of the placenta during labour. Some fine-structural aspects of the decidua which are important to the formation of the zone of placental separation are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00935993
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  • 10
    Electronic Resource
    Electronic Resource
    Fourier Transform Infrared Spectrometry: Application to Gas Analysis in Pressurized Fluidized Bed Combustion (1992)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 64 (1992), S. 861-861 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.3306409139
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