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Genes expressed in human tumor endothelium (2000)

B. St Croix ; C. Rago ; V. Velculescu ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 289(5482): 1197-202.

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Publication Date: 2000-08-19

Description: To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts predominantly expressed in the endothelium, 79 were differentially expressed, including 46 that were specifically elevated in tumor-associated endothelium. Several of these genes encode extracellular matrix proteins, but most are of unknown function. Most of these tumor endothelial markers were expressed in a wide range of tumor types, as well as in normal vessels associated with wound healing and corpus luteum formation. These studies demonstrate that tumor and normal endothelium are distinct at the molecular level, a finding that may have significant implications for the development of anti-angiogenic therapies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉St Croix, B -- Rago, C -- Velculescu, V -- Traverso, G -- Romans, K E -- Montgomery, E -- Lal, A -- Riggins, G J -- Lengauer, C -- Vogelstein, B -- Kinzler, K W -- CA57345/CA/NCI NIH HHS/ -- CA62924/CA/NCI NIH HHS/ -- CGAP S98-146A/PHS HHS/ -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1197-202.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947988" target="_blank"〉PubMed〈/a〉

Keywords: Biomarkers, Tumor ; Cell Separation ; Cells, Cultured ; Colon/*blood supply/metabolism ; Colorectal Neoplasms/*blood supply/genetics/metabolism/pathology ; Corpus Luteum/blood supply/metabolism ; Endothelium, Vascular/cytology/*metabolism/pathology ; Extracellular Matrix Proteins/genetics ; Female ; Gene Expression ; *Gene Expression Profiling ; Humans ; Intestinal Mucosa/blood supply/cytology/pathology ; Neoplasms/blood supply/genetics/metabolism ; Neovascularization, Pathologic/*genetics ; Neovascularization, Physiologic/genetics ; RNA, Messenger/genetics/metabolism ; Rectum/*blood supply/metabolism ; Tumor Cells, Cultured

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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A phosphatase associated with metastasis of colorectal cancer (2001)

S. Saha ; A. Bardelli ; P. Buckhaults ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 294(5545): 1343-6. doi: 10.1126/science.1065817.

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Publication Date: 2001-10-13

Description: To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saha, S -- Bardelli, A -- Buckhaults, P -- Velculescu, V E -- Rago, C -- St Croix, B -- Romans, K E -- Choti, M A -- Lengauer, C -- Kinzler, K W -- Vogelstein, B -- CA 62924/CA/NCI NIH HHS/ -- CA43460/CA/NCI NIH HHS/ -- CA57345/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1343-6. Epub 2001 Oct 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, The Oncology Center, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11598267" target="_blank"〉PubMed〈/a〉

Keywords: Adenoma/enzymology/genetics/pathology ; Chromosome Mapping ; Chromosomes, Human, Pair 8 ; Colon/enzymology ; Colorectal Neoplasms/*enzymology/*genetics/pathology ; Gene Amplification ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Gene Library ; Humans ; Immediate-Early Proteins/*genetics/metabolism ; Intestinal Mucosa/enzymology ; Neoplasm Metastasis/*genetics ; Neoplasm Proteins ; Neoplasm Staging ; Polymerase Chain Reaction ; Protein Tyrosine Phosphatases/*genetics/metabolism ; Rectum/enzymology

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics