Publication Date:
1998-09-25
Description:
If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naive test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (〈10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moser, E I -- Krobert, K A -- Moser, M B -- Morris, R G -- New York, N.Y. -- Science. 1998 Sep 25;281(5385):2038-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Norwegian University of Science and Technology, 7034 Trondheim, Norway.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9748165" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Dentate Gyrus/physiology
;
Electric Stimulation
;
Electrodes, Implanted
;
Evoked Potentials
;
Excitatory Postsynaptic Potentials
;
Hippocampus/*physiology
;
Long-Term Potentiation/*physiology
;
Male
;
Maze Learning/*physiology
;
Perforant Pathway
;
Rats
;
Synapses/physiology
;
Tetany
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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