Publication Date:
2011-08-24
Description:
We thank Monetti et al. (1) for their thoughtful comparison between our two studies (2, 3). Although the main conclusion of our reports differs, several aspects of both studies are similar. We used the same transgenic line of low DGAT2-overexpressing mice on the same C57BL/6NHsd background strain. Notably, the DGAT2 mice accumulate hepatic triglyceride and diacylglycerol (DAG) compared with WT mice in both studies. By using LC-MS/MS combined with cell fractionation, we measured individual species of DAGs in different compartments and reported that the active DAG compartment associated with hepatic insulin resistance appears to be cytosolic (3). The critical difference...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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