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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 3 (1955), S. 400-402 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 11 (1977), S. 71-74 
    ISSN: 1432-1041
    Keywords: Phenytoin ; radioimmunoassay ; saliva ; cerebrospinal fluid ; non-protein bound ; epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A simple, specific and rapid radioimmunoassay (RIA) method for the assessment of nonprotein bound (‘free’) phenytoin (DPH) concentrations in mixed saliva is described. Epileptic patients on maintenance phenytoin therapy have mixed saliva phenytoin concentrations similar to ‘free’ drug levels measured directly in serum or cerebrospinal fluid (CSF). Salivary phenytoin levels are approximately 10% of the total serum level in treated epileptic patients and in normal subjects after ingestion of a single oral dose. The half time of disappearance of phenytoin after 100 or 300 mg doses is 12.2±3.0 (SD) h in serum and 12.3±3.2 (SD) h in saliva. This method of assessing the biologically active fraction of the drug may be particularly valuable in situations where serum protein binding is abnormal or in drug interactions. It is also non-invasive and requires small sample volumes (20µl) and may therefore be valuable in paediatric practice and in pharmacokinetic studies in which multiple venepunctures would otherwise be required.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 450-453 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE classical method of calculating renal clearance of a compound utilizes equation (I)1: Renal clearance = CU.F/C (1) where Cu is urine concentration, F is urine flow rate, and G is serum or plasma concentration. Since Cu.F = dke/cU (equation 2), equation 1 assumes urinary excretion rate is ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 175-177 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In presenting various laboratory data which identified FAV and FPV as being one and the same agent, materials and methods are discussed only in outline because they have been presented more completely in preceding publications. The FAV virus was represented by 5 per cent suspansions in Eagle's ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 280-280 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DR GABELLA has produced an informative account of the structure of the autonomic nervous system. It is given in small compass (160 pages), and the author has also restricted his historical introduction to just over a page. The book then examines the structural anatomy of sympathetic ganglia and ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 301-301 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THIS excellent little monograph reviews information on known members of the genus Parvovirus in the Family Parvoviridae. The volume of data accumulated during the past decade on members of this genus is so great (over 300 major references), and is so complex, that Dr Siegl has wisely concentrated ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 953-954 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In September 1967 two of us (R. H. J. and J. L. C.) had the opportunity of making three journeys with Bedouin in the North Arabian Desert of Jordan as part of a preliminary physiological study of desert inhabitants. The first journey lasting 4 days was made by camel with four Bedouin from the ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 622-623 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Previous publications have described the original isolation of a possible FP virus strain2, have demonstrated the association of this strain with the disease syndrome3'4 and have described some properties of this prototype LV strain of FP (refs. 5 and 6). The strain is shown to be representative of ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 192-193 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Where n approaches unity, deformation tends to viscous (Newtonian) flow and, in this event, large elongations are possible since there is no enhancement of the rate of diminution of cross-sectional area. A common circumstance where metals deform by viscous flow is where vacancy creep4 occurs, but a ...
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 39 (1984), S. 0 
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Comparisons between some aspects of grazing and ruminating behaviour by sheep recorded automatically and by manual observation are reported.Behaviour was recorded manually and automatically on four swards with surface heights of 3, 6, 9 and 12 cm. The automatic recording method gave significantly higher biting rates (78 v 67 ± 2·4 bites min−1) than manual recording. Possible reasons for these differences are discussed. For recordings during ruminating there was no significant difference between the two recording methods.As sward surface height increased biting rate decreased by 4·6 (± 0.65) and 2·9 (± 0·87) bites min−1 cm−1, and masticating rate increased by 4·5 (± 1·13) and 3·7 (± 0·95) chews min−1 cm−1 for the manual and automatic recording methods respectively.It is concluded that the automatic recording system gives higher rates for jaw movements during grazing than manual recording but there is little difference between the two methods for activities recorded during ruminating.
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