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  • 1
    Electronic Resource
    Electronic Resource
    Genetics of histocompatibility in mice (1981)
    Springer
    Immunogenetics 13 (1981), S. 327-337 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The response to spleen cells incompatible at defined histocompatibility, H, loci was studied using the popliteal lymph-node enlargement test to establish its applicability as a method for detecting minor H antigens. This test was able to detect H-2 and H-Y antigens as well as most of the minor H antigens represented by 23 different strains congenic with C57BL/6By. Responses of both naive and immunized recipients were examined, and time-courses of the response were obtained for ten donor strains. These curves revealed that different antigens elicited responses that differed in timing and magnitude of peak enlargements, and that the two parameters were not closely correlated. Both the peak magnitude and the slope of the primary response were correlated with skin-graft rejection, however. The response to individual minor antigens did not appear to be dose-dependent above a threshold. Irradiation of donor cells had strain-dependent effects on the elicited response. Irradiation of recipients appeared to abrogate the primary response but not the responses of previously primed recipients in the combination tested. None of the responses studied had any demonstrable graft-versus-host component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364498
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  • 2
    Electronic Resource
    Electronic Resource
    Genetics of histocompatibility in mice (1981)
    Springer
    Immunogenetics 14 (1981), S. 63-71 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The H-Y antigen and minor H antigens defined by eight C57BL/6By (B6) congenic mouse strains were studied for their distribution among 13 different tissues. Antigen expression was detected by implanting B6 recipients with organ fragments from congenic strain donors that had been previously grafted with B6 bone marrow to minimize the number of allogeneic passenger leukocytes. Successfully immunized recipients were identified by the enlargement of their popliteal lymph nodes following footpad challenge with spleen cells of the donor type. No two strains had identical patterns of expression of their distinguishing antigens. The data provide evidence for differences in levels of minor H-antigen expression among different tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344300
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  • 3
    Electronic Resource
    Electronic Resource
    Teratocarcinoma transplantation antigens are encoded in the H-2 region (1983)
    Springer
    Immunogenetics 18 (1983), S. 137-145 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Evidence is presented for the existence of teratocarcinoma transplantation antigens (Gt) encoded within the H-2 complex and present also on adult tissues. It has not been possible to separate these Gt loci from H-2 by recombination, and Gt factors map to each end of the H-2 complex. Previous reports indicating separation of all Gt loci from H-2 are reinterpreted. One class of such apparent recombinants has been shown to result from the outgrowth of tumor variants in mice of resistant genotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368542
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  • 4
    Electronic Resource
    Electronic Resource
    Tailskin grafts do not show accelerated rejection on splenectomized hosts (1978)
    Springer
    Immunogenetics 6 (1978), S. 483-486 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01563939
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  • 5
    Electronic Resource
    Electronic Resource
    Antigenic competition between minor (Non-H-2) histocompatibility antigens (1981)
    Springer
    Immunogenetics 13 (1981), S. 451-455 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346026
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  • 6
    Electronic Resource
    Electronic Resource
    Mice coisogenically immunized against H-2 class I antigens on transfected l cells reject transplanted embryonal carcinoma cells (1985)
    Springer
    Immunogenetics 22 (1985), S. 533-541 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Evidence is presented of the ability of H-2 class I antigens to function as teratocarcinoma transplantation (Gt) antigens. Coisogenic immunization against H-2 class I antigens expressed on transfected L cells is shown to induce resistance to embryonic carcinoma (EC) cell allografts. The Kb, Db, Dd, and, in appropriate recipients, Ld antigens can function as Gt antigens. The protocol presented may be useful for the molecular identification of other genes encoding histocompatibility antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430301
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  • 7
    Electronic Resource
    Electronic Resource
    Genetic influences other thanH-2 on the rejection of male skin grafts by female mice (1979)
    Springer
    Immunogenetics 8 (1979), S. 373-376 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561448
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  • 8
    Electronic Resource
    Electronic Resource
    Genetics of histocompatibility in mice (1980)
    Springer
    Immunogenetics 11 (1980), S. 363-372 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Twenty-five congenic mouse strains differing at distinguishable minor (non-H−2) histocompatibility loci were paired in 71 different combinations. F1 offspring were used as skin-graft donors for more than 4000 recipients to test whether immune responses to parental strain antigens were statistically independent. Thirty-four (48 percent) of the 71 combinations were predicted adequately by an independent response hypothesis. A simple additive model was consistent with 39 (55 percent) of the observed responses, although 18 of these were among those in agreement with the independent hypothesis. A synergistic response faster than that predicted by either the independent or additive response model was seen in 12 (17 percent) of the combinations. The remaining 5 percent were not well described by any of these models. No strain was represented with unusual frequency among those involved in synergistic interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01567803
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  • 9
    Electronic Resource
    Electronic Resource
    H-2 class I and Gt (H-2) antigens are identical: Evidence from H-2 mutant mice (1986)
    Springer
    Immunogenetics 23 (1986), S. 271-273 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373023
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  • 10
    Electronic Resource
    Electronic Resource
    Antigraft responses to the H-28c antigen by B6 and B6D2F1 mice (1988)
    Springer
    Immunogenetics 27 (1988), S. 159-166 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The survival of minor H antigen-bearing skin grafts from donors congenic with C57BL/6 (B6) was compared in B6, B6D2, and AB6 hybrid recipients. In a case singled out for further study, B6 mice were found to reject HW 110 skin (H-28c antigen) rapidly, whereas B6D2 mice rejected HW110 skin much more slowly and variably. Both major histocompatibility complex (MHC)-linked and non-MHC genes appeared to affect the survival of HW110 strain skin grafts on B6 and B6D2 recipients. Results of several experiments appear to rule out the sharing of H-28° epitopes between donors and recipients as an explanation for the relatively poor response of B6D2 mice to HW 110 skin grafts. Experiments involving bone marrow chimeras produced by the reciprocal exchange of bone marrow between irradiated B6 and B6D2 mice suggest that bone marrow-derived donor cells and non-bone-marrow-derived host cells each contribute to the immune response phenotype with respect to the H-28° antigen. An attempt was made to determine whether B6D2 mice that failed to reject HW110 strain skin grafts possessed suppressor cells specific for the H-28c antigen. Spleen cells from poorly responsive B6D2 mice failed to suppress the rejection of HW 110 skin grafts when assayed in immunodeficient mice that were provided with cells from immune 136132 donors that were highly responsive to HW110 skin grafts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346581
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