ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
A commercial available amphiphilic polymer, Cholesterol terminated PEO (Chol-PEO), was used as novel biomimetic drug delivery system. The association behavior of Chol-PEOs in aqueous solution was studied by fluorescence probe technique and transmission electron microscope (TEM). Fluorescence excitation spectra for pyrene probe solubilized in the aggregates of Chol-PEOs suggested the presence of a critical micelle concentration (cmc) in water. TEM images of the aggregates suggested that the PEO block formed the biocompatible micelle coronas and the cholesterol block formed the hydrophobic micelle cores. These new biomimetic diblock copolymers were evaluated as nanocapsules for the delivery of hydrophobic drugs and drug release behavior of a hydrophobic anti-cancer drug, adriamycin (ADR), was examined
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.465.pdf
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