Publication Date:
2000-06-01
Description:
Disodium Monofluorophoshate (MFP), a highly water soluble drug, was incorporated in polyacrylate resin microspheres by using the solvent-evaporation technique. The process is based on dispersing the acetone solution of the drug and the polymer in liquid paraffin. Eudragit RS 100/S 100 in a 3:1 ratio turned out as the best coating material. The influence of the main manufacturing factors, namely polymer-drug ratio, addition of magnesium stearate, size of the beads, production temperature and speed of stirring, on the technological characteristics of the microspheres, like release rate of the drug, shape, drug-loading and size of the particle were investigated. The findings resulted in a formulation, which obtains the desired controlled release of the drug in a convenient oral system.
Print ISSN:
0036-8709
Electronic ISSN:
2218-0532
Topics:
Chemistry and Pharmacology
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