Publication Date:
2019
Description:
Abstract
Acute pancreatitis (AP) often progresses to recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). We investigated the relationship between the use of insulin after AP and progression from AP to RAP or CP, as well as the effect of diabetes status on it. Using nationwide pharmaceutical dispensing data and hospital discharge data, insulin‐naïve individuals were followed from first AP admission. Multivariable time‐dependent Cox regression analyses were conducted. In the overall cohort (n=10,190), ever‐use of insulin was associated with an increased risk of progression to RAP or CP (adjusted HR, 1.70; 95% CI, 1.31–2.20). This risk remained increased in individuals with pre‐existing diabetes (adjusted HR, 1.45; 95% CI, 1.04–2.00), those with diabetes after AP (3.87; 1.20–12.46), and those without diabetes (2.80; 1.25–6.25). The findings suggest that AP individuals who receive insulin might be at a heightened risk of progression of pancreatitis, irrespective of diabetes status.
Print ISSN:
0009-9236
Electronic ISSN:
1532-6535
Topics:
Chemistry and Pharmacology
,
Medicine
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