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  • 1
    Publication Date: 2014-03-11
    Description: Author(s): V. Kozhevnikov, R. J. Wijngaarden, J. de Wit, and C. Van Haesendonck To address unsolved fundamental problems of the intermediate state (IS), the equilibrium magnetic flux structure and the critical field in a high-purity type-I superconductor (indium film) are investigated using magneto-optical imaging with a three-dimensional vector magnet and electrical transport ... [Phys. Rev. B 89, 100503] Published Mon Mar 10, 2014
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2014-05-05
    Description: An overview is presented of the recent advances in understanding the B[e] phenomenon among blue supergiant stars in light of high-angular resolution observations and with an emphasis on the results obtained by means of long baseline optical stellar interferometry. The focus of the review is on the circumstellar material and evolutionary phase of B[e] supergiants, but recent results on dust production in regular blue supergiants are also highlighted.
    Print ISSN: 1687-7969
    Electronic ISSN: 1687-7977
    Topics: Physics
    Published by Hindawi
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  • 3
    Publication Date: 2015-04-06
    Description: We used Herschel Hi-GAL (Herschel infrared Galactic Plane survey) data to determine whether massive young stellar objects (MYSOs) are resolved at 70 μm and to study their envelope density distribution. Our analysis of three relatively isolated sources in the l  = 30° and 59° Galactic fields show that the objects are partially resolved at 70 μm. The Herschel Hi-GAL survey data have a high scan velocity which makes unresolved and partially resolved sources appear elongated in the 70 μm images. We analysed the two scan directions separately and examine the intensity profile perpendicular to the scan direction. Spherically symmetric radiative transfer models with a power-law density distribution were used to study the circumstellar matter distribution. Single dish submm data were also included to study how different spatial information affects the fitted density distribution. The density distribution which best fits both the 70 μm intensity profile and spectral energy distribution has an average index of ~0.5. This index is shallower than expected and is probably due to the dust emission from bipolar outflow cavity walls not accounted for in the spherical models. We conclude that 2D axisymmetric models and Herschel images at low scan speeds are needed to better constrain the matter distribution around MYSOs.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 4
    Publication Date: 2002-04-16
    Description: One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in XPD, a gene encoding a DNA helicase that functions in both repair and transcription and that is mutated in the human disorder trichothiodystrophy (TTD). TTD mice were found to exhibit many symptoms of premature aging, including osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, infertility, and reduced life-span. TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Boer, Jan -- Andressoo, Jaan Olle -- de Wit, Jan -- Huijmans, Jan -- Beems, Rudolph B -- van Steeg, Harry -- Weeda, Geert -- van der Horst, Gijsbertus T J -- van Leeuwen, Wibeke -- Themmen, Axel P N -- Meradji, Morteza -- Hoeijmakers, Jan H J -- AG 17242-02/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 May 17;296(5571):1276-9. Epub 2002 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Genetics Center, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University, 3000 DR Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11950998" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Aging, Premature/*etiology ; Animals ; Apoptosis ; Bone Density ; Cachexia/etiology ; Crosses, Genetic ; *DNA Damage ; DNA Helicases/genetics/*physiology ; *DNA Repair ; DNA-Binding Proteins/genetics/physiology ; Female ; Fertility ; Gene Targeting ; Growth Disorders/etiology/genetics ; Hair Diseases/genetics ; Kyphosis/etiology/genetics/pathology ; Male ; Mice ; Mutation ; Oxidative Stress ; Phenotype ; Point Mutation ; Proteins/genetics/*physiology ; RNA-Binding Proteins/genetics/physiology ; *Transcription Factors ; Transcription, Genetic ; Xeroderma Pigmentosum Group A Protein ; Xeroderma Pigmentosum Group D Protein
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-12-21
    Description: Determination of an exoplanet's mass is a key to understanding its basic properties, including its potential for supporting life. To date, mass constraints for exoplanets are predominantly based on radial velocity (RV) measurements, which are not suited for planets with low masses, large semimajor axes, or those orbiting faint or active stars. Here, we present a method to extract an exoplanet's mass solely from its transmission spectrum. We find good agreement between the mass retrieved for the hot Jupiter HD 189733b from transmission spectroscopy with that from RV measurements. Our method will be able to retrieve the masses of Earth-sized and super-Earth planets using data from future space telescopes that were initially designed for atmospheric characterization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Wit, Julien -- Seager, Sara -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1473-7. doi: 10.1126/science.1245450.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357312" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2005-04-23
    Description: How plants recognize pathogens and activate defense is still mysterious. Direct interaction between pathogen avirulence (Avr) proteins and plant disease resistance proteins is the exception rather than the rule. During infection, Cladosporium fulvum secretes Avr2 protein into the apoplast of tomato leaves and, in the presence of the extracellular leucine-rich repeat receptor-like Cf-2 protein, triggers a hypersensitive response (HR) that also requires the extracellular tomato cysteine protease Rcr3. We show here that Avr2 binds and inhibits Rcr3 and propose that the Rcr3-Avr2 complex enables the Cf-2 protein to activate an HR.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rooney, Henrietta C E -- Van't Klooster, John W -- van der Hoorn, Renier A L -- Joosten, Matthieu H A J -- Jones, Jonathan D G -- de Wit, Pierre J G M -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1783-6. Epub 2005 Apr 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845874" target="_blank"〉PubMed〈/a〉
    Keywords: Biotin/metabolism ; Cladosporium/*metabolism/pathogenicity ; Cysteine Endopeptidases/*metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Extracellular Fluid/metabolism ; Fungal Proteins/*physiology ; Hydrogen-Ion Concentration ; Immunoprecipitation ; Leucine/*analogs & derivatives/pharmacology ; Lycopersicon esculentum/*enzymology/genetics/*microbiology ; Pichia ; Plant Diseases/*microbiology ; Plant Leaves/metabolism/microbiology ; Plant Proteins/*metabolism ; Recombinant Fusion Proteins/antagonists & inhibitors/metabolism ; Tobacco
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-05-03
    Description: Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as 'ultracool dwarfs'. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive enough to sustain hydrogen fusion), and represents about 15 per cent of the population of astronomical objects near the Sun. Core-accretion theory predicts that, given the small masses of these ultracool dwarfs, and the small sizes of their protoplanetary disks, there should be a large but hitherto undetected population of terrestrial planets orbiting them--ranging from metal-rich Mercury-sized planets to more hospitable volatile-rich Earth-sized planets. Here we report observations of three short-period Earth-sized planets transiting an ultracool dwarf star only 12 parsecs away. The inner two planets receive four times and two times the irradiation of Earth, respectively, placing them close to the inner edge of the habitable zone of the star. Our data suggest that 11 orbits remain possible for the third planet, the most likely resulting in irradiation significantly less than that received by Earth. The infrared brightness of the host star, combined with its Jupiter-like size, offers the possibility of thoroughly characterizing the components of this nearby planetary system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gillon, Michael -- Jehin, Emmanuel -- Lederer, Susan M -- Delrez, Laetitia -- de Wit, Julien -- Burdanov, Artem -- Van Grootel, Valerie -- Burgasser, Adam J -- Triaud, Amaury H M J -- Opitom, Cyrielle -- Demory, Brice-Olivier -- Sahu, Devendra K -- Bardalez Gagliuffi, Daniella -- Magain, Pierre -- Queloz, Didier -- England -- Nature. 2016 May 2;533(7602):221-4. doi: 10.1038/nature17448.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut d'Astrophysique et de Geophysique, Universite de Liege, Allee du 6 Aout 19C, 4000 Liege, Belgium. ; NASA Johnson Space Center, 2101 NASA Parkway, Houston, Texas, 77058, USA. ; Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. ; Center for Astrophysics and Space Science, University of California San Diego, La Jolla, California 92093, USA. ; Institute of Astronomy, Madingley Road, Cambridge CB3 0HA, UK. ; Astrophysics Group, Cavendish Laboratory, 19 J J Thomson Avenue, Cambridge, CB3 0HE, UK. ; Indian Institute of Astrophysics, Koramangala, Bangalore 560 034, India.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27135924" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-03-31
    Description: Over the past decade, observations of giant exoplanets (Jupiter-size) have provided key insights into their atmospheres, but the properties of lower-mass exoplanets (sub-Neptune) remain largely unconstrained because of the challenges of observing small planets. Numerous efforts to observe the spectra of super-Earths--exoplanets with masses of one to ten times that of Earth--have so far revealed only featureless spectra. Here we report a longitudinal thermal brightness map of the nearby transiting super-Earth 55 Cancri e (refs 4, 5) revealing highly asymmetric dayside thermal emission and a strong day-night temperature contrast. Dedicated space-based monitoring of the planet in the infrared revealed a modulation of the thermal flux as 55 Cancri e revolves around its star in a tidally locked configuration. These observations reveal a hot spot that is located 41 +/- 12 degrees east of the substellar point (the point at which incident light from the star is perpendicular to the surface of the planet). From the orbital phase curve, we also constrain the nightside brightness temperature of the planet to 1,380 +/- 400 kelvin and the temperature of the warmest hemisphere (centred on the hot spot) to be about 1,300 kelvin hotter (2,700 +/- 270 kelvin) at a wavelength of 4.5 micrometres, which indicates inefficient heat redistribution from the dayside to the nightside. Our observations are consistent with either an optically thick atmosphere with heat recirculation confined to the planetary dayside, or a planet devoid of atmosphere with low-viscosity magma flows at the surface.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Demory, Brice-Olivier -- Gillon, Michael -- de Wit, Julien -- Madhusudhan, Nikku -- Bolmont, Emeline -- Heng, Kevin -- Kataria, Tiffany -- Lewis, Nikole -- Hu, Renyu -- Krick, Jessica -- Stamenkovic, Vlada -- Benneke, Bjorn -- Kane, Stephen -- Queloz, Didier -- England -- Nature. 2016 Apr 14;532(7598):207-9. doi: 10.1038/nature17169. Epub 2016 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Astrophysics Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE, UK. ; Institut d'Astrophysique et de Geophysique, Universite of Liege, allee du 6 Aout 17, 4000 Liege, Belgium. ; Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. ; Institute of Astronomy, University of Cambridge, Cambridge CB3 0HA, UK. ; NaXys, Department of Mathematics, University of Namur, 8 Rempart de la Vierge, 5000 Namur, Belgium. ; University of Bern, Center for Space and Habitability, Sidlerstrasse 5, CH-3012, Bern, Switzerland. ; Astrophysics Group, School of Physics, University of Exeter, Stocker Road, Exeter EX4 4QL, UK. ; Space Telescope Science Institute, Baltimore, Maryland 21218, USA. ; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA. ; Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California 91125, USA. ; Spitzer Science Center, MS 220-6, California Institute of Technology, Jet Propulsion Laboratory, Pasadena, California 91125, USA. ; Department of Physics and Astronomy, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27027283" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2017-03-03
    Description: Nature Physics 13, 276 (2017). doi:10.1038/nphys3942 Authors: A. Caratti o Garatti, B. Stecklum, R. Garcia Lopez, J. Eislöffel, T. P. Ray, A. Sanna, R. Cesaroni, C. M. Walmsley, R. D. Oudmaijer, W. J. de Wit, L. Moscadelli, J. Greiner, A. Krabbe, C. Fischer, R. Klein & J. M. Ibañez Solar-mass stars form via disk-mediated accretion. Recent findings indicate that this process is probably episodic in the form of accretion bursts, possibly caused by disk fragmentation. Although it cannot be ruled out that high-mass young stellar objects arise from the coalescence of their low-mass brethren, the latest results suggest that they more likely form via disks. It follows that disk-mediated accretion bursts should occur. Here we report on the discovery of the first disk-mediated accretion burst from a roughly twenty-solar-mass high-mass young stellar object. Our near-infrared images show the brightening of the central source and its outflow cavities. Near-infrared spectroscopy reveals emission lines typical for accretion bursts in low-mass protostars, but orders of magnitude more luminous. Moreover, the released energy and the inferred mass-accretion rate are also orders of magnitude larger. Our results identify disk-accretion as the common mechanism of star formation across the entire stellar mass spectrum.
    Print ISSN: 1745-2473
    Electronic ISSN: 1745-2481
    Topics: Physics
    Published by Springer Nature
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  • 10
    Publication Date: 2020-09-25
    Description: Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM), which can be spliced into two isoforms (PKM1, PKM2). This is of interest, because PKM2 redirects glycolytic flux towards biosynthetic pathways, which might contribute to muscle hypertrophy too. We first investigated whether resistance exercise changes PKM isoform expression in growing human skeletal muscle and found that PKM2 abundance increases after six weeks of resistance training, whereas PKM1 decreases. Second, we determined that Pkm2 expression is higher in fast compared to slow fiber types in rat skeletal muscle. Third, by inducing hypertrophy in differentiated C2C12 cells and by selectively silencing Pkm1 and/or Pkm2 with siRNA, we found that PKM2 limits myotube growth. We conclude that PKM2 contributes to hypertrophy in C2C12 myotubes and indicates a changed metabolic environment within hypertrophying human skeletal muscle fibers. PKM2 is preferentially expressed in fast muscle fibers and may partly contribute to the increased potential for hypertrophy in fast fibers.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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