Publication Date:
1981-08-28
Description:
Morphine has been found in cow and human milk at concentrations of 200 to 500 nanograms per liter. Multistep purification yields a material that has immunological, biological, pharmacological, and chemical properties identical to those of morphine. Similar morphine-like material, which has been tentatively identified in some common plant sources, may be a ubiquitous dietary constituent and a possible source for the material in milk. Since morphine (mu) receptors have a low affinity for enkephalins, and since morphine-like materials have been described in brain and intestine, it is possible that morphine in food may be the source of this material and a normal ligand specific for mu receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Sabatka, J J -- Chang, K J -- Brent, D A -- Findlay, J W -- Cuatrecasas, P -- New York, N.Y. -- Science. 1981 Aug 28;213(4511):1010-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267691" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cattle
;
Diet
;
Female
;
Humans
;
Ligands
;
Milk/*analysis
;
Milk, Human/analysis
;
Morphine/*analysis/metabolism
;
Receptors, Opioid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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