Publication Date:
2016-01-30
Description:
The mammalian Y chromosome is considered a symbol of maleness, as it encodes a gene driving male sex determination, Sry, as well as a battery of other genes important for male reproduction. We previously demonstrated in the mouse that successful assisted reproduction can be achieved when the Y gene contribution is limited to only two genes, Sry and spermatogonial proliferation factor Eif2s3y. Here, we replaced Sry by transgenic activation of its downstream target Sox9, and Eif2s3y, by transgenic overexpression of its X chromosome-encoded homolog Eif2s3x. The resulting males with no Y chromosome genes produced haploid male gametes and sired offspring after assisted reproduction. Our findings support the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamauchi, Yasuhiro -- Riel, Jonathan M -- Ruthig, Victor A -- Ortega, Egle A -- Mitchell, Michael J -- Ward, Monika A -- HD072380/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 29;351(6272):514-6. doi: 10.1126/science.aad1795.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Road, Honolulu, HI 96822, USA. ; Aix-Marseille Universite, INSERM, GMGF UMR_S 910, 13385 Marseille, France. ; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Road, Honolulu, HI 96822, USA. mward@hawaii.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26823431" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Eukaryotic Initiation Factor-2/*genetics
;
Female
;
Gene Dosage
;
Haploidy
;
Male
;
Mice
;
Mice, Transgenic
;
Reproductive Techniques, Assisted
;
SOX9 Transcription Factor/*genetics
;
Sex-Determining Region Y Protein/*genetics
;
Spermatogenesis/*genetics
;
Spermatogonia/cytology/metabolism
;
X Chromosome/*genetics
;
Y Chromosome/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
