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  • 1
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    Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-19
    Description: Tissue degradation by the matrix metalloproteinase gelatinase A is pivotal to inflammation and metastases. Recognizing the catalytic importance of substrate-binding exosites outside the catalytic domain, we screened for extracellular substrates using the gelatinase A hemopexin domain as bait in the yeast two-hybrid system. Monocyte chemoattractant protein-3 (MCP-3) was identified as a physiological substrate of gelatinase A. Cleaved MCP-3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation. This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McQuibban, G A -- Gong, J H -- Tam, E M -- McCulloch, C A -- Clark-Lewis, I -- Overall, C M -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1202-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Catalytic Domain ; Cell Line ; Chemokine CCL7 ; Chemokines/antagonists & inhibitors/metabolism ; Chemotaxis, Leukocyte ; Collagen/metabolism ; *Cytokines ; Enzyme Activation ; Gene Library ; Hemopexin/chemistry/metabolism ; Humans ; Inflammation/*metabolism/pathology ; Mass Spectrometry ; Matrix Metalloproteinase 2/chemistry/*metabolism ; Mice ; Monocyte Chemoattractant Proteins/*metabolism ; Protein Binding ; Protein Structure, Tertiary ; Receptors, Chemokine/antagonists & inhibitors/metabolism ; Recombinant Proteins/metabolism ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Two-Hybrid System Techniques
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    TEM and DSC studies on the synthetic diamond grown from Fe–Ni–C–B system under HPHT (2006)
    Springer
    Details
    Publication Date: 2006-03-10
    Print ISSN: 0022-2461
    Electronic ISSN: 1573-4803
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Springer
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  • 3
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    Geochronology, geochemistry and petrogenesis of the late Palaeoproterozoic A-type granites from the Dunhuang block, SE Tarim Craton, China: implications for the break-up of the Columbia supercontinent (2014)
    Cambridge University Press
    Details
    Publication Date: 2014-07-23
    Description: The discovery of c . 1.77 Ga A-type granite in the Tarim Craton (TC) provides the first evidence that supports an extensional event related to fragmentation of the Columbia supercontinent in the late Palaeoproterozoic. We present laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U–Pb ages, Lu–Hf isotopic data and the whole-rock geochemical and Nd isotopic data of A-type granites in the Dunhuang area in the SE Tarim Craton. Zircon U–Pb dating for three granite samples indicate that they were emplaced at c . 1.77 Ga. Zircons from these granites have Hf ( t ) values ranging from –5.9 to 8.7, corresponding to two-stage model ages of 1.9–2.7 Ga. These granites exhibit the following petrological geochemical characteristics that are typical of A-type granite: (a) high content of SiO 2 and alkalis (i.e. high K 2 O + Na 2 O with K 2 O/Na 2 O 〉 1), enrichment of high-field-strength elements (HFSE) and rare Earth elements (REE) (except for Eu) and extreme depletion of Ba, Sr, P, Ti and Eu; (b) 10000 x Ga/Al ratios in the Dunhuang granites of 3.5–4.4, with an average value of 3.79 which is similar to the global average of 3.75 for A-type granites; (c) the presence of characteristic minerals such as amphibole, sphene and perthite; and (d) zirconium saturation temperature results indicate that the Dunhuang granites have high initial magmatic temperatures in the range 887–950°C, similar to those of typical of A-type granites. Whole-rock Nd ( t ) values range from –2.5 to –6.2 and T DM model ages from 2.3 to 2.7 Ga. Nd–Hf isotopic and whole-rock geochemical data indicate that these granites were most likely derived from the late Archean crustal source in a post-collisional/post-orogenic extensional tectonic environment. The late Palaeoproterozoic A-type granites in the TC could be correlated with those of the North China Craton (NCC), India and the Canadian Shield, thus demonstrating extensional tectonics and break-up of the Columbia supercontinent.
    Print ISSN: 0016-7568
    Electronic ISSN: 1469-5081
    Topics: Geosciences
    Published by Cambridge University Press
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  • 4
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    Efficient dam break flood simulation methods for developing a preliminary evacuation plan after the Wenchuan Earthquake (2012)
    Copernicus
    Details
    Publication Date: 2012-01-11
    Description: The Xiaojiaqiao barrier lake, which was the second largest barrier lake formed by the Wenchuan Earthquake had seriously threatened the lives and property of the population downstream. The lake was finally dredged successfully on 7 June 2008. Because of the limited time available to conduct an inundation potential analysis and make an evacuation plan, barrier lake information extraction and real-time dam break flood simulation should be carried out quickly, integrating remote sensing and geographic information system (GIS) techniques with hydrologic/hydraulic analysis. In this paper, a technical framework and several key techniques for this real-time preliminary evacuation planning are introduced. An object-oriented method was used to extract hydrological information on the barrier lake from unmanned aerial vehicle (UAV) remote sensing images. The real-time flood routine was calculated by using shallow-water equations, which were solved by means of a finite volume scheme on multiblock structured grids. The results of the hydraulic computations are visualized and analyzed in a 3-D geographic information system for inundation potential analysis, and an emergency response plan is made. The results show that if either a full-break or a half-break situation had occurred for the Chapinghe barrier lake on 19 May 2008, then the Xiaoba Town region and the Sangzao Town region would have been affected, but the downstream towns would have been less influenced. Preliminary evacuation plans under different dam break situations can be effectively made using these methods.
    Print ISSN: 1561-8633
    Electronic ISSN: 1684-9981
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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