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  • 1
    Publication Date: 2014-01-16
    Description: Author(s): N. Vafaei-Najafabadi, K. A. Marsh, C. E. Clayton, W. An, W. B. Mori, C. Joshi, W. Lu, E. Adli, S. Corde, M. Litos, S. Li, S. Gessner, J. Frederico, A. S. Fisher, Z. Wu, D. Walz, R. J. England, J. P. Delahaye, C. I. Clarke, M. J. Hogan, and P. Muggli We show through experiments and supporting simulations that propagation of a highly relativistic and dense electron bunch through a plasma can lead to distributed injection of electrons, which depletes the accelerating field, i.e., beam loads the wake. The source of the injected electrons is ionizat... [Phys. Rev. Lett. 112, 025001] Published Wed Jan 15, 2014
    Keywords: Plasma and Beam Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 2
    Publication Date: 2013-10-10
    Description: Author(s): W. An, M. Zhou, N. Vafaei-Najafabadi, K. A. Marsh, C. E. Clayton, C. Joshi, W. B. Mori, W. Lu, E. Adli, S. Corde, M. Litos, S. Li, S. Gessner, J. Frederico, M. J. Hogan, D. Walz, J. England, J. P. Delahaye, and P. Muggli Strategies for mitigating ionization-induced beam head erosion in an electron-beam-driven plasma wakefield accelerator (PWFA) are explored when the plasma and the wake are both formed by the transverse electric field of the beam itself. Beam head erosion can occur in a preformed plasma because of a ... [Phys. Rev. ST Accel. Beams 16, 101301] Published Wed Oct 09, 2013
    Keywords: New Acceleration Techniques
    Electronic ISSN: 1098-4402
    Topics: Physics
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  • 3
    Publication Date: 2015-11-25
    Description: Given the highly heterogeneous character of brain malignancies and the associated implication for its proper diagnosis and treatment, finding biomarkers that better characterize this disease from a molecular standpoint is imperative. In this study, we evaluated CD146 as a potential molecular target for diagnosis and targeted therapy of glioblastoma multiforme...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2015-08-29
    Description: Several large earthquakes in the Hellenic subduction zone have been documented in historical records from around the eastern Mediterranean, but the relative seismic quiescence of the region over the period of instrumental observation means that the exact locations of these earthquakes and their tectonic significance are not known. We present AMS radiocarbon dates from uplifted late Holocene palæoshorelines from the island of Rhodes, showing that uplift is most consistent with a single large ( M W  ≥ 7.7) reverse-faulting earthquake between about 2000 BC and 200 BC. Analysis of the uplift treating the earthquake as a dislocation in an elastic half-space shows a predominantly reverse-faulting event with a slip vector oblique to the direction of convergence between Rhodes and Nubia. We suggest that the fault responsible for the uplift dips at an angle of 30–60° above the more gently dipping oblique subduction interface. The highly oblique convergence across the eastern Hellenic plate boundary zone appears to be partitioned into reverse slip on faults that strike parallel to the boundary and strike-parallel or oblique slip on the subduction interface. Hydrodynamical simulation of tsunami propagation from a range of tectonically plausible sources suggests that earthquakes on the fault uplifting Rhodes represent a significant tsunami hazard for Rhodes and SW Turkey, and also possibly for Cyprus and the Nile Delta.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
    Publication Date: 2011-12-13
    Description: Analytical Chemistry DOI: 10.1021/ac201544h
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 6
    Publication Date: 1998-07-24
    Description: The venom of predatory marine snails is a rich source of natural products that act on specific receptors and ion channels within the mammalian nervous system. A 41-amino acid peptide, final sigma-conotoxin GVIIIA, was purified on the basis of its ability to inactivate the 5-HT3 receptor, an excitatory serotonin-gated ion channel. final sigma-Conotoxin contains a brominated tryptophan residue, which may be important for peptide activity because the endogenous ligand for the 5-HT3 receptor is a hydroxylated derivative of tryptophan. final sigma-Conotoxin inactivates the 5-HT3 receptor through competitive antagonism and is a highly selective inhibitor of this receptor. Serotonin receptors can now be included among the molecular targets of natural polypeptide neurotoxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England, L J -- Imperial, J -- Jacobsen, R -- Craig, A G -- Gulyas, J -- Akhtar, M -- Rivier, J -- Julius, D -- Olivera, B M -- GM44298/GM/NIGMS NIH HHS/ -- GM48677/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Jul 24;281(5376):575-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9677203" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acids/analysis ; Animals ; Benzamides/pharmacology ; Bicyclo Compounds, Heterocyclic/pharmacology ; Binding Sites ; Cell Line ; Cloning, Molecular ; *Conotoxins ; DNA, Complementary ; Ion Channel Gating ; Ion Channels/*antagonists & inhibitors ; Molecular Sequence Data ; Mollusk Venoms/chemistry/genetics/isolation & purification/*pharmacology ; Peptides, Cyclic/pharmacology ; Receptors, Serotonin/*metabolism ; Receptors, Serotonin, 5-HT3 ; Receptors, Serotonin, 5-HT4 ; Recombinant Fusion Proteins/antagonists & inhibitors/metabolism ; Recombinant Proteins/antagonists & inhibitors ; Serotonin/metabolism/pharmacology ; Serotonin Antagonists/chemistry/isolation & purification/*pharmacology ; Snails/*chemistry ; Tryptophan/analysis/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Nature Publishing Group (NPG)
    Publication Date: 2010-02-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England, John -- England -- Nature. 2010 Jan 14;463(7278):159. doi: 10.1038/463159a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NSERC Northern Research Chair at the University of Alberta, Edmonton, Alberta T6G 2E3, Canada. john.england@ualberta.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075900" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arctic Regions ; Canada ; Ecology/*economics/instrumentation ; *Ecosystem ; Ice Cover ; Leadership ; Research/*economics/instrumentation ; Research Support as Topic/economics/*organization & administration
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2013-10-01
    Description: The enormous size and cost of current state-of-the-art accelerators based on conventional radio-frequency technology has spawned great interest in the development of new acceleration concepts that are more compact and economical. Micro-fabricated dielectric laser accelerators (DLAs) are an attractive approach, because such dielectric microstructures can support accelerating fields one to two orders of magnitude higher than can radio-frequency cavity-based accelerators. DLAs use commercial lasers as a power source, which are smaller and less expensive than the radio-frequency klystrons that power today's accelerators. In addition, DLAs are fabricated via low-cost, lithographic techniques that can be used for mass production. However, despite several DLA structures having been proposed recently, no successful demonstration of acceleration in these structures has so far been shown. Here we report high-gradient (beyond 250 MeV m(-1)) acceleration of electrons in a DLA. Relativistic (60-MeV) electrons are energy-modulated over 563 +/- 104 optical periods of a fused silica grating structure, powered by a 800-nm-wavelength mode-locked Ti:sapphire laser. The observed results are in agreement with analytical models and electrodynamic simulations. By comparison, conventional modern linear accelerators operate at gradients of 10-30 MeV m(-1), and the first linear radio-frequency cavity accelerator was ten radio-frequency periods (one metre) long with a gradient of approximately 1.6 MeV m(-1) (ref. 5). Our results set the stage for the development of future multi-staged DLA devices composed of integrated on-chip systems. This would enable compact table-top accelerators on the MeV-GeV (10(6)-10(9) eV) scale for security scanners and medical therapy, university-scale X-ray light sources for biological and materials research, and portable medical imaging devices, and would substantially reduce the size and cost of a future collider on the multi-TeV (10(12) eV) scale.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peralta, E A -- Soong, K -- England, R J -- Colby, E R -- Wu, Z -- Montazeri, B -- McGuinness, C -- McNeur, J -- Leedle, K J -- Walz, D -- Sozer, E B -- Cowan, B -- Schwartz, B -- Travish, G -- Byer, R L -- England -- Nature. 2013 Nov 7;503(7474):91-4. doi: 10.1038/nature12664. Epub 2013 Nov 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Physics, Stanford University, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24077116" target="_blank"〉PubMed〈/a〉
    Keywords: *Acceleration ; Aluminum Oxide ; Diagnostic Imaging/instrumentation ; *Electrons ; Equipment Design ; *Lasers ; Particle Accelerators/*instrumentation ; X-Rays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2014-11-07
    Description: High-efficiency acceleration of charged particle beams at high gradients of energy gain per unit length is necessary to achieve an affordable and compact high-energy collider. The plasma wakefield accelerator is one concept being developed for this purpose. In plasma wakefield acceleration, a charge-density wake with high accelerating fields is driven by the passage of an ultra-relativistic bunch of charged particles (the drive bunch) through a plasma. If a second bunch of relativistic electrons (the trailing bunch) with sufficient charge follows in the wake of the drive bunch at an appropriate distance, it can be efficiently accelerated to high energy. Previous experiments using just a single 42-gigaelectronvolt drive bunch have accelerated electrons with a continuous energy spectrum and a maximum energy of up to 85 gigaelectronvolts from the tail of the same bunch in less than a metre of plasma. However, the total charge of these accelerated electrons was insufficient to extract a substantial amount of energy from the wake. Here we report high-efficiency acceleration of a discrete trailing bunch of electrons that contains sufficient charge to extract a substantial amount of energy from the high-gradient, nonlinear plasma wakefield accelerator. Specifically, we show the acceleration of about 74 picocoulombs of charge contained in the core of the trailing bunch in an accelerating gradient of about 4.4 gigavolts per metre. These core particles gain about 1.6 gigaelectronvolts of energy per particle, with a final energy spread as low as 0.7 per cent (2.0 per cent on average), and an energy-transfer efficiency from the wake to the bunch that can exceed 30 per cent (17.7 per cent on average). This acceleration of a distinct bunch of electrons containing a substantial charge and having a small energy spread with both a high accelerating gradient and a high energy-transfer efficiency represents a milestone in the development of plasma wakefield acceleration into a compact and affordable accelerator technology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Litos, M -- Adli, E -- An, W -- Clarke, C I -- Clayton, C E -- Corde, S -- Delahaye, J P -- England, R J -- Fisher, A S -- Frederico, J -- Gessner, S -- Green, S Z -- Hogan, M J -- Joshi, C -- Lu, W -- Marsh, K A -- Mori, W B -- Muggli, P -- Vafaei-Najafabadi, N -- Walz, D -- White, G -- Wu, Z -- Yakimenko, V -- Yocky, G -- England -- Nature. 2014 Nov 6;515(7525):92-5. doi: 10.1038/nature13882.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA. ; 1] SLAC National Accelerator Laboratory, Menlo Park, California 94025, USA [2] Department of Physics, University of Oslo, 0316 Oslo, Norway. ; Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, California 90095, USA. ; Department of Electrical Engineering, University of California Los Angeles, Los Angeles, California 90095, USA. ; Department of Engineering Physics, Tsinghua University, Beijing 100084, China. ; Max Planck Institute for Physics, Munich 80805, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25373678" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1978-04-21
    Description: Field observations on northeast Ellesmere Island indicate that the maximum advance of the northwest Greenland Ice Sheet was about 100 kilometers beyond its present margin. This occurred before the outermost Ellesmere Island ice advance, which took place more than 30,000 years before present (B.P.). Recession from the Ellesmere Island ice margin began at least 28,000 to 30,000 and possibly more than 35,000 years B.P. During this sequence of glacial events, significant land areas remained free of ice. The late Wisconsin ice extent along both northeast Ellesmere Island and northwest Greenland was extremely limited, leaving an ice-free corridor along Kennedy and Robeson channels. Recession from these ice margins is indicated by initial postglacial emergence around 8100 to 8400 years B.P. The relatively minor extent of late Wisconsin ice in the High Arctic probably reflects a period of extreme aridity occasioned by the buildup of the Laurentide Ice Sheet to the south.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉England, J -- Bradley, R S -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):265-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17745546" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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