Publication Date:
1983-04-01
Description:
Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kales, A -- Soldatos, C R -- Bixler, E O -- Kales, J D -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):95-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6131538" target="_blank"〉PubMed〈/a〉
Keywords:
Anti-Anxiety Agents/*adverse effects/metabolism/therapeutic use
;
Benzodiazepines/adverse effects/therapeutic use
;
Flurazepam/therapeutic use
;
Half-Life
;
Humans
;
Midazolam
;
Sleep/drug effects
;
Sleep Initiation and Maintenance Disorders/drug therapy/*etiology
;
Triazolam/adverse effects/therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink