Publication Date:
1992-07-24
Description:
It has long been thought that anteroposterior (A-P) pattern in the vertebrate central nervous system is induced in the embryo's dorsal ectoderm exclusively by signals passing vertically from underlying, patterned dorsal mesoderm. Explants from early gastrulae of the frog Xenopus laevis were prepared in which vertical contact between dorsal ectoderm and mesoderm was prevented but planar contact was maintained. In these, four position-specific neural markers (engrailed-2, Krox-20, XlHbox 1, and XlHbox 6) were expressed in the ectoderm in the same A-P order as in the embryo. Thus, planar signals alone, following a path available in the normal embryo, can induce A-P neural pattern.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doniach, T -- Phillips, C R -- Gerhart, J C -- GM19363/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1992 Jul 24;257(5069):542-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1636091" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biomarkers
;
Cell Adhesion Molecules, Neuronal/analysis
;
Central Nervous System/*embryology
;
Ectoderm/physiology
;
Embryo, Nonmammalian/cytology/physiology
;
Gastrula/physiology
;
Gene Expression
;
Mesoderm/physiology
;
Organ Culture Techniques
;
Xenopus laevis/*embryology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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