Publication Date:
1997-11-21
Description:
The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16. daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, K -- Dorman, J B -- Rodan, A -- Kenyon, C -- AG11816/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1997 Nov 14;278(5341):1319-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0554, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9360933" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/genetics
;
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Caenorhabditis elegans/*genetics/physiology
;
*Caenorhabditis elegans Proteins
;
Cloning, Molecular
;
DNA, Complementary
;
Forkhead Transcription Factors
;
Genes, Helminth
;
Humans
;
Insulin/physiology
;
Longevity/genetics
;
Molecular Sequence Data
;
Mutation
;
Nuclear Proteins/genetics
;
Phenotype
;
Receptor, Insulin/genetics/physiology
;
Sequence Alignment
;
Somatomedins/physiology
;
Transcription Factors/chemistry/*genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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