Publication Date:
1984-06-15
Description:
Iontophoretic injection of phosphorylase kinase, a Ca2+-calmodulin-dependent protein kinase, increased input resistance, enhanced the long-lasting depolarization component of the light response, and reduced the early transient outward K+ current, IA, and the late K+ currents, IB, in type B photoreceptors of Hermissenda crassicornis in a Ca2+-dependent manner. Since behavioral and biophysical studies have shown that similar membrane changes persist after associative conditioning, these results suggest that Ca2+-dependent protein phosphorylation could mediate the long-term modulation of specific K+ channels as a step in the generation of a coditioned behavioral change.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Acosta-Urquidi, J -- Alkon, D L -- Neary, J T -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1254-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328653" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials/drug effects
;
Animals
;
*Association Learning
;
Horseshoe Crabs
;
Ion Channels/drug effects
;
Iontophoresis
;
*Learning
;
Light
;
Mollusca
;
Phosphorylase Kinase/*pharmacology
;
Photoreceptor Cells/*drug effects
;
Potassium/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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