ISSN:
1432-1041
Keywords:
Key words Cirrhosis
;
Citalopram
;
Renal impairment
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: To compare the pharmacokinetics of the antidepressant citalopram and its metabolites demethylcitalopram and didemethylcitalopram in subjects with moderate renal insufficiency and subjects with hepatic cirrhosis with that in healthy subjects. Methods: Pharmacokinetic parameters from three individual, open-label, phase I trials were derived following single oral or intravenous citalopram dose (40 mg) to healthy subjects and a single oral dose (20 mg) to patients. Serum and urine concentrations of citalopram and metabolites were determined using a validated HPLC method. Results: The absolute bioavailability of citalopram tablets in healthy subjects was 80%. The renal clearance was a minor component (〈20%) of the total elimination of citalopram. Serum Cmax and t max for citalopram were essentially unaffected by the occurrence of renal or hepatic disease. In comparison with healthy subjects, renal impairment was associated with a significant reduction in the renal elimination of citalopram and its two metabolites and a slight prolongation of serum citalopram t 1/2 (49.5 h vs 36.8 h in healthy subjects).␣Cirrhosis resulted in significant decrease in citalopram CLoral␣(0.21 vs 0.33 l · h−1· kg−1 in healthy subjects) and increase in Vz· f −1, with an approximately twofold increase in t 1/2 (83.4 h vs 36.8 h in healthy subjects). Indices of renal (creatinine or 51Cr-EDTA clearances) and hepatic (galactose elimination capacity or Child-Pugh score) function were poor predictors of the changes in the pharmacokinetics of citalopram and its metabolites in these populations. Conclusion: No reduction of citalopram dosage is warranted in patients with moderately impaired renal function. However, that may not apply for patients with severe renal failure. In patients with impaired hepatic function, prescription of a lower dosage of citalopram may be appropriate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050452
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